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Christopher D. Fleming, Ph.D.

Affiliations: 
2007 Biochemistry and Biophysics University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Structural Studies of Dynamic Cellular Processes
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"Christopher Fleming"
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Matthew R. Redinbo grad student 2007 UNC Chapel Hill
 (Structural insights into xenobiotic and organophosphate binding by human carboxylesterase 1 and efforts made towards the characterization of the androgen receptor modulator MAGE-11.)

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Publications

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Hemmert AC, Otto TC, Wierdl M, et al. (2010) Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin. Molecular Pharmacology. 77: 508-16
Fleming CD, Edwards CC, Kirby SD, et al. (2007) Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry. 46: 5063-71
Huang H, Fleming CD, Nishi K, et al. (2005) Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chemical Research in Toxicology. 18: 1371-7
Fleming CD, Bencharit S, Edwards CC, et al. (2005) Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. Journal of Molecular Biology. 352: 165-77
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