Bret D. Wallace, Ph.D.

2012 Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Structural Studies of Dynamic Cellular Processes
"Bret Wallace"
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Matthew R. Redinbo grad student 2012 UNC Chapel Hill
 (Alleviating Cancer Drug Toxicity Through Targeted Inhibition of a Bacterial Enzyme and Exploring the Structural and Functional Properties of the Xenobiotic Nuclear Receptor PXR.)
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Bhatt AP, Pellock SJ, Biernat KA, et al. (2020) Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy. Proceedings of the National Academy of Sciences of the United States of America
Wallace BD, Roberts AB, Pollet RM, et al. (2015) Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chemistry & Biology. 22: 1238-49
Roberts AB, Wallace BD, Venkatesh MK, et al. (2013) Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity. Molecular Pharmacology. 84: 208-17
Wallace BD, Redinbo MR. (2013) The human microbiome is a source of therapeutic drug targets. Current Opinion in Chemical Biology. 17: 379-84
Wallace BD, Betts L, Talmage G, et al. (2013) Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα. Journal of Molecular Biology. 425: 2561-77
Wallace BD, Redinbo MR. (2013) Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective. Drug Metabolism Reviews. 45: 79-100
Wallace BD, Edwards JS, Wallen JR, et al. (2012) Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights. Biochemistry. 51: 7699-711
LoGuidice A, Wallace BD, Bendel L, et al. (2012) Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice. The Journal of Pharmacology and Experimental Therapeutics. 341: 447-54
Wallace BD, Wang H, Lane KT, et al. (2010) Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science (New York, N.Y.). 330: 831-5
Parsonage D, Newton GL, Holder RC, et al. (2010) Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry. 49: 8398-414
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