Bret D. Wallace, Ph.D.
Affiliations: | 2012 | Chemistry | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
Structural Studies of Dynamic Cellular ProcessesGoogle:
"Bret Wallace"Mean distance: 10.32 | S | N | B | C | P |
Parents
Sign in to add mentorMatthew R. Redinbo | grad student | 2012 | UNC Chapel Hill | |
(Alleviating Cancer Drug Toxicity Through Targeted Inhibition of a Bacterial Enzyme and Exploring the Structural and Functional Properties of the Xenobiotic Nuclear Receptor PXR.) |
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Publications
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Challa AP, Hu X, Zhang YQ, et al. (2022) Virtual Screening for the Discovery of Microbiome β-Glucuronidase Inhibitors to Alleviate Cancer Drug Toxicity. Journal of Chemical Information and Modeling. 62: 1783-1793 |
Bhatt AP, Pellock SJ, Biernat KA, et al. (2020) Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy. Proceedings of the National Academy of Sciences of the United States of America |
Appel CD, Feld GK, Wallace BD, et al. (2016) Structure of the Sirtuin-linked Macrodomain SAV0325 from Staphylococcus aureus. Protein Science : a Publication of the Protein Society |
Wallace BD, Roberts AB, Pollet RM, et al. (2015) Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chemistry & Biology. 22: 1238-49 |
Pollet R, Wallace B, Robers A, et al. (2015) Pharmaceutical Control of the Microbiome The Faseb Journal. 29 |
Roberts AB, Wallace BD, Venkatesh MK, et al. (2013) Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity. Molecular Pharmacology. 84: 208-17 |
Wallace BD, Redinbo MR. (2013) The human microbiome is a source of therapeutic drug targets. Current Opinion in Chemical Biology. 17: 379-84 |
Wallace BD, Betts L, Talmage G, et al. (2013) Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα. Journal of Molecular Biology. 425: 2561-77 |
Wallace BD, Redinbo MR. (2013) Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective. Drug Metabolism Reviews. 45: 79-100 |
Wallace BD, Edwards JS, Wallen JR, et al. (2012) Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights. Biochemistry. 51: 7699-711 |