Karen L. Buchmueller, Ph.D.

2002 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Structural and Chemical Biology of the Transcriptome
"Karen Buchmueller"
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Kevin M. Weeks grad student 2002 UNC Chapel Hill
 (Identification and structural characterization of an RNA collapsed state.)
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Smith AE, Buchmueller KL. (2011) Molecular basis for the inhibition of HMGA1 proteins by distamycin A. Biochemistry. 50: 8107-16
Brown T, Taherbhai Z, Sexton J, et al. (2007) Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin. Bioorganic & Medicinal Chemistry. 15: 474-83
Buchmueller KL, Bailey SL, Matthews DA, et al. (2006) Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm. Biochemistry. 45: 13551-65
Flores LV, Staples AM, Mackay H, et al. (2006) Synthesis and evaluation of an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase IIalpha promoter. Chembiochem : a European Journal of Chemical Biology. 7: 1722-9
Buchmueller KL, Taherbhai Z, Howard CM, et al. (2005) Design of a hairpin polyamide, ZT65B, for targeting the inverted CCAAT box (ICB) site in the multidrug resistant (MDR1) gene. Chembiochem : a European Journal of Chemical Biology. 6: 2305-11
Buchmueller KL, Staples AM, Uthe PB, et al. (2005) Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamides. Nucleic Acids Research. 33: 912-21
Buchmueller KL, Staples AM, Howard CM, et al. (2005) Extending the language of DNA molecular recognition by polyamides: unexpected influence of imidazole and pyrrole arrangement on binding affinity and specificity. Journal of the American Chemical Society. 127: 742-50
Buchmueller KL, Horick SM, Howard CM, et al. (2005) Recognition of specific DNA sequences by stacked pyrrole- and imidazole-containing polyamides: An efficient screening method based on competitive dialysis Letters in Drug Design and Discovery. 2: 137-142
Uthe PB, Staples AM, Turlington M, et al. (2005) Novel picolinic acid-containing pyrrole-imidazole polyamides: Synthesis and T·G mismatched base pair recognition Heterocyclic Communications. 11: 163-166
Buchmueller KL, Weeks KM. (2004) Tris-borate is a poor counterion for RNA: a cautionary tale for RNA folding studies. Nucleic Acids Research. 32: e184
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