Cristina Gherghe, Ph.D.

Affiliations: 
2007 Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Structural and Chemical Biology of the Transcriptome
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"Cristina Gherghe"
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Kevin M. Weeks grad student 2007 UNC Chapel Hill
 (Mechanism of retroviral genomic RNA dimerization and packaging.)
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Publications

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Duan J, Gherghe C, Liu D, et al. (2012) Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. The Embo Journal. 31: 429-42
Gherghe CM, Duan J, Gong J, et al. (2011) Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 1836-43
Gherghe C, Lombo T, Leonard CW, et al. (2010) Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome. Proceedings of the National Academy of Sciences of the United States of America. 107: 19248-53
Gherghe C, Leonard CW, Gorelick RJ, et al. (2010) Secondary structure of the mature ex virio Moloney murine leukemia virus genomic RNA dimerization domain. Journal of Virology. 84: 898-906
Gherghe CM, Leonard CW, Ding F, et al. (2009) Native-like RNA tertiary structures using a sequence-encoded cleavage agent and refinement by discrete molecular dynamics. Journal of the American Chemical Society. 131: 2541-6
Gherghe CM, Shajani Z, Wilkinson KA, et al. (2008) Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. Journal of the American Chemical Society. 130: 12244-5
Gherghe CM, Mortimer SA, Krahn JM, et al. (2008) Slow conformational dynamics at C2'-endo nucleotides in RNA. Journal of the American Chemical Society. 130: 8884-5
Gherghe C, Weeks KM. (2006) The SL1-SL2 (stem-loop) domain is the primary determinant for stability of the gamma retroviral genomic RNA dimer. The Journal of Biological Chemistry. 281: 37952-61
Badorrek CS, Gherghe CM, Weeks KM. (2006) Structure of an RNA switch that enforces stringent retroviral genomic RNA dimerization. Proceedings of the National Academy of Sciences of the United States of America. 103: 13640-5
Gherghe CM, Krahn JM, Weeks KM. (2005) Crystal structures, reactivity and inferred acylation transition states for 2'-amine substituted RNA. Journal of the American Chemical Society. 127: 13622-8
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