Francis K. Insaidoo, Ph.D.

Affiliations: 
2010 University of Notre Dame, Notre Dame, IN, United States 
Area:
molecular recognition and cellular communication
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Brian M. Baker grad student 2010 Notre Dame
 (Dynamics of peptides bound to class I major histocompatibility complex proteins: Implications for T-cell receptor recognition in the immune response.)
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Publications

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Rockwell L, Bao H, Insaidoo F, et al. (2022) Cation exchange as a single polishing step for conjugated peptides. Biotechnology Progress. e3238
Insaidoo FK, Borbulevych OY, Hossain M, et al. (2011) Loss of T cell antigen recognition arising from changes in peptide and major histocompatibility complex protein flexibility: implications for vaccine design. The Journal of Biological Chemistry. 286: 40163-73
Aggen DH, Chervin AS, Insaidoo FK, et al. (2011) Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors. Protein Engineering, Design & Selection : Peds. 24: 361-72
Insaidoo FK, Zajicek J, Baker BM. (2009) A general and efficient approach for NMR studies of peptide dynamics in class I MHC peptide binding grooves. Biochemistry. 48: 9708-10
Armstrong KM, Insaidoo FK, Baker BM. (2008) Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities. Journal of Molecular Recognition : Jmr. 21: 275-87
Borbulevych OY, Insaidoo FK, Baxter TK, et al. (2007) Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition. Journal of Molecular Biology. 372: 1123-36
Davis-Harrison RL, Insaidoo FK, Baker BM. (2007) T cell receptor binding transition states and recognition of peptide/MHC. Biochemistry. 46: 1840-50
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