Casey C. Cosner, Ph.D.
Affiliations: | 2011 | University of Notre Dame, Notre Dame, IN, United States |
Area:
Drug Design & Discovery, Synthetic ChemistryGoogle:
"Casey Cosner"Mean distance: 8.43 | S | N | B | C | P |
Parents
Sign in to add mentor| Paul M. Helquist | grad student | 2011 | Notre Dame | |
| (Potential Niemann-Pick type C disease therapeutics: Synthesis of pyrrolinones and enolate-derived thiadiazoles, and the development of a palladium-catalyzed alpha alkenylation reaction as a means to prepare trichostatin A.) | ||||
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Publications
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| Brockway AJ, Cosner CC, Volkov OA, et al. (2016) Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound. Synthesis. 48: 2065-2068 |
| Pearson GL, Mellett N, Chu KY, et al. (2014) Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells. Diabetologia. 57: 129-39 |
| Ankner T, Cosner CC, Helquist P. (2013) Palladium- and nickel-catalyzed alkenylation of enolates Chemistry - a European Journal. 19: 1858-1871 |
| Cosner CC, Bhaskara Reddy Iska V, Chatterjee A, et al. (2013) Evolution of concise and flexible synthetic strategies for trichostatic acid and the potent histone deacetylase inhibitor trichostatin A European Journal of Organic Chemistry. 162-172 |
| Cosner CC, Helquist P. (2011) Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction. Organic Letters. 13: 3564-7 |
| Pipalia NH, Cosner CC, Huang A, et al. (2011) Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 108: 5620-5 |
| Cosner CC, Cabrera PJ, Byrd KM, et al. (2011) Selective oxidation of benzylic and allylic alcohols using Mn(OAc)3/catalytic 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. Organic Letters. 13: 2071-3 |
| Rosenbaum AI, Cosner CC, Mariani CJ, et al. (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. Journal of Medicinal Chemistry. 53: 5281-9 |
| Cosner CC, Markiewicz JT, Bourbon P, et al. (2009) Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics. Journal of Medicinal Chemistry. 52: 6494-8 |