Pauline Bourbon, Ph.D.
Affiliations: | 2013 | University of Notre Dame, Notre Dame, IN, United States |
Area:
Drug Design & Discovery, Synthetic ChemistryGoogle:
"Pauline Bourbon"Mean distance: 8.43 | S | N | B | C | P |
Parents
Sign in to add mentorPaul M. Helquist | grad student | 2013 | Notre Dame | |
(Development of potential Niemann-Pick C therapeutics and the synthesis of caged nicotinamide and cholesterol to gain a better understanding of cholesterol biosynthesis and trafficking.) |
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Publications
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Pearson GL, Mellett N, Chu KY, et al. (2014) Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells. Diabetologia. 57: 129-39 |
Bourbon P, Peng Q, Ferraudi G, et al. (2013) Development of carbamate-tethered coumarins as phototriggers for caged nicotinamide. Bioorganic & Medicinal Chemistry Letters. 23: 6321-4 |
Bourbon P, Peng Q, Ferraudi G, et al. (2013) Synthesis and photochemical behavior of coumarin-caged cholesterol. Bioorganic & Medicinal Chemistry Letters. 23: 2162-5 |
Bourbon P, Peng Q, Ferraudi G, et al. (2012) Synthesis, photophysical, photochemical, and computational studies of coumarin-labeled nicotinamide derivatives. The Journal of Organic Chemistry. 77: 2756-62 |
Pierre F, Chua PC, O'Brien SE, et al. (2011) Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer. Molecular and Cellular Biochemistry. 356: 37-43 |
Pipalia NH, Cosner CC, Huang A, et al. (2011) Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 108: 5620-5 |
Pierre F, O'Brien SE, Haddach M, et al. (2011) Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties. Bioorganic & Medicinal Chemistry Letters. 21: 1687-91 |
Pierre F, Chua PC, O'Brien SE, et al. (2011) Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. Journal of Medicinal Chemistry. 54: 635-54 |
Cosner CC, Markiewicz JT, Bourbon P, et al. (2009) Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics. Journal of Medicinal Chemistry. 52: 6494-8 |