David C. Smithson, Ph.D.
Affiliations: | 2009 | Chemistry and Chemical Biology | University of California, San Francisco, San Francisco, CA |
Area:
Medicinal ChemistryGoogle:
"David Smithson"Mean distance: 8.53 | S | N | B | C | P |
Parents
Sign in to add mentor| R. Kip Guy | grad student | 2004-2009 | UCSF | |
| (Discovery of novel inhibitors of ornithine decarboxylase in Trypanosoma brucei: Development and application of a targeted high-throughput screening program.) | ||||
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Publications
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| Zhao Y, Cushing PR, Smithson DC, et al. (2018) Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports |
| Zhao Y, Cushing PR, Smithson DC, et al. (2018) Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports |
| Ortiz D, Guiguemde WA, Hammill JT, et al. (2017) Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening. Plos Neglected Tropical Diseases. 11: e0006157 |
| Zhang J, Bowling JJ, Smithson D, et al. (2016) Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum. Malaria Journal. 15: 270 |
| Madoux F, Janovick JA, Smithson D, et al. (2015) Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening. Assay and Drug Development Technologies. 13: 16-24 |
| Yang J, Liang Q, Wang M, et al. (2014) UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries. Journal of Natural Products. 77: 902-9 |
| Conn PM, Smithson DC, Hodder PS, et al. (2014) Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 83: 38-51 |
| Hwang JY, Smithson DC, Holbrook G, et al. (2013) Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei. Bioorganic & Medicinal Chemistry Letters. 23: 4127-31 |
| Conn PM, Smith E, Hodder P, et al. (2013) High-throughput screen for pharmacoperones of the vasopressin type 2 receptor. Journal of Biomolecular Screening. 18: 930-7 |
| Hwang JY, Smithson D, Zhu F, et al. (2013) Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry. 56: 2850-60 |