Xianwen Chen, Ph.D.

Affiliations: 
2011 Chemistry Ohio State University, Columbus, Columbus, OH 
Area:
chemical biology, medicinal chemistry
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"Xianwen Chen"
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Dehua Pei grad student 2011 Ohio State
 (Profiling the substrate specificity of protein tyrosine phosphatases by combinatorial library screening.)
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Selner NG, Luechapanichkul R, Chen X, et al. (2014) Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases. Biochemistry. 53: 397-412
Luechapanichkul R, Chen X, Taha HA, et al. (2013) Specificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes. The Journal of Biological Chemistry. 288: 6498-510
Ren L, Chen X, Luechapanichkul R, et al. (2011) Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2. Biochemistry. 50: 2339-56
Chen X, Ren L, Kim S, et al. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. The Journal of Biological Chemistry. 285: 31268-76
Chen X, Tan PH, Zhang Y, et al. (2009) On-bead screening of combinatorial libraries: reduction of nonspecific binding by decreasing surface ligand density. Journal of Combinatorial Chemistry. 11: 604-11
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