Kari-Ann Draker, Ph.D.
Affiliations: | 2004 | McMaster University, Hamilton, ON, Canada |
Area:
Antibiotic resistance; chemically synthesizing antibioticsGoogle:
"Kari-Ann Draker"Mean distance: 8.51 | S | N | B | C | P |
Parents
Sign in to add mentor| Gerard D. Wright | grad student | 2004 | McMaster University | |
| (Characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium.) | ||||
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Publications
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| Draker KA, Wright GD. (2004) Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivation. Biochemistry. 43: 446-54 |
| Draker KA, Northrop DB, Wright GD. (2003) Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity. Biochemistry. 42: 6565-74 |
| Draker KA, Boehr DD, Elowe NH, et al. (2003) Functional annotation of putative aminoglycoside antibiotic modifying proteins in Mycobacterium tuberculosis H37Rv. The Journal of Antibiotics. 56: 135-42 |
| Boehr DD, Draker KA, Koteva K, et al. (2003) Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes. Chemistry & Biology. 10: 189-96 |
| Sucheck SJ, Wong AL, Koeller KM, et al. (2000) Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes [11] Journal of the American Chemical Society. 122: 5230-5231 |
| Wybenga-Groot LE, Draker Ka, Wright GD, et al. (1999) Crystal structure of an aminoglycoside 6'-N-acetyltransferase: Defining the GCN5-related N-acetyltransferase superfamily fold Structure. 7: 497-507 |
| DiGiammarino EL, Draker KA, Wright GD, et al. (1998) Solution studies of isepamicin and conformational comparisons between isepamicin and butirosin A when bound to an aminoglycoside 6'-N-acetyltransferase determined by NMR spectroscopy. Biochemistry. 37: 3638-44 |