David J. Donnelly, Ph.D.

Affiliations: 
2006 State University of New York, Buffalo, Buffalo, NY, United States 
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"David Donnelly"
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Michael R. Detty grad student 2006 SUNY Buffalo
 (The design and synthesis of chalcogenoxanthylium dyes for use as photosensitizers in photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT).)
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Publications

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Tombline G, Holt JJ, Gannon MK, et al. (2008) ATP occlusion by P-glycoprotein as a surrogate measure for drug coupling. Biochemistry. 47: 3294-307
Calitree B, Donnelly DJ, Holt JJ, et al. (2007) Tellurium analogues of rosamine and rhodamine dyes: Synthesis, structure, 125Te NMR, and heteroatom contributions to excitation energies Organometallics. 26: 6248-6257
Wagner SJ, Skripchenko A, Thompson-Montgomery D, et al. (2006) Use of a red cell band 3-ligand/antioxidant to improve red cell storage properties following virucidal phototeatment with chalcogenoxanthylium photosensitizers. Photochemistry and Photobiology. 82: 1595-600
Tombline G, Donnelly DJ, Holt JJ, et al. (2006) Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state. Biochemistry. 45: 8034-47
Wagner SJ, Skripchenko A, Donnelly DJ, et al. (2005) Chalcogenoxanthylium photosensitizers for the photodynamic purging of blood-borne viral and bacterial pathogens. Bioorganic & Medicinal Chemistry. 13: 5927-35
Gibson SL, Holt JJ, Ye M, et al. (2005) Structure-activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells. Bioorganic & Medicinal Chemistry. 13: 6394-403
Del Valle DJ, Donnelly DJ, Holt JJ, et al. (2005) 2,7-Bis-N,N-dimethylaminochalcogenoxanthen-9-ones via electrophilic cyclization with phosphorus oxychloride Organometallics. 24: 3807-3810
Gibson SL, Hilf R, Donnelly DJ, et al. (2004) Analogues of tetramethylrosamine as transport molecules for and inhibitors of P-glycoprotein-mediated multidrug resistance. Bioorganic & Medicinal Chemistry. 12: 4625-31
Detty MR, Prasad PN, Donnelly DJ, et al. (2004) Synthesis, properties, and photodynamic properties in vitro of heavy-chalcogen analogues of tetramethylrosamine. Bioorganic & Medicinal Chemistry. 12: 2537-44
Ohulchanskyy TY, Donnelly DJ, Detty MR, et al. (2004) Heteroatom substitution induced changes in excited-state photophysics and singlet oxygen generation in chalcogenoxanthylium dyes: Effect of sulfur and selenium substitutions Journal of Physical Chemistry B. 108: 8668-8672
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