Amber M. King, Ph.D.

Affiliations: 
2011 Pharmaceutical Sciences University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
biological mechanisms of therapeutic agents
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Harold Kohn grad student 2011 UNC Chapel Hill
 (Synthesis and pharmacological evaluation of primary amino acid derivatives (PAADs): Novel neurological agents for the treatment of epilepsy and neuropathic pain.)
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Publications

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King AM, Yang XF, Wang Y, et al. (2012) Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation. Acs Chemical Neuroscience. 3: 1037-49
Baruah PK, Dinsmore J, King AM, et al. (2012) Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides. Bioorganic & Medicinal Chemistry. 20: 3551-64
King AM, De Ryck M, Kaminski R, et al. (2011) Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide. Journal of Medicinal Chemistry. 54: 6432-42
King AM, Salomé C, Salomé-Grosjean E, et al. (2011) Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties. Journal of Medicinal Chemistry. 54: 6417-31
King AM, Salomé C, Dinsmore J, et al. (2011) Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities. Journal of Medicinal Chemistry. 54: 4815-30
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