Douglas A. Jeffery, Ph.D.

Affiliations: 
2000 University of California, San Francisco, San Francisco, CA 
Area:
signal transduction, transcriptional regulation
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"Douglas Jeffery"
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Parents

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Erin K. O'Shea grad student 2000 UCSF
 (Function and regulation of the cyclin -CDK Pho80 -Pho85.)
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Publications

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Xie Y, Zamponi R, Charlat O, et al. (2013) Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin. Embo Reports. 14: 1120-6
Harbinski F, Craig VJ, Sanghavi S, et al. (2012) Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth. Cancer Discovery. 2: 948-59
Schmitt EK, Riwanto M, Sambandamurthy V, et al. (2011) The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease. Angewandte Chemie (International Ed. in English). 50: 5889-91
Kulasingam V, Smith CR, Batruch I, et al. (2008) "Product ion monitoring" assay for prostate-specific antigen in serum using a linear ion-trap. Journal of Proteome Research. 7: 640-7
Pan Z, Scheerens H, Li SJ, et al. (2007) Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. Chemmedchem. 2: 58-61
Pan Z, Jeffery DA, Chehade K, et al. (2006) Development of activity-based probes for trypsin-family serine proteases. Bioorganic & Medicinal Chemistry Letters. 16: 2882-5
Wu J, Katrekar A, Honigberg LA, et al. (2006) Identification of substrates of human protein-tyrosine phosphatase PTPN22. The Journal of Biological Chemistry. 281: 11002-10
Tang J, Yu CL, Williams SR, et al. (2005) Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein. The Journal of Biological Chemistry. 280: 41077-89
Setti EL, Davis D, Janc JW, et al. (2005) 3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity. Bioorganic & Medicinal Chemistry Letters. 15: 1529-34
Jeffery DA, Bogyo M. (2004) Chemical proteomics and its application to drug discovery. Drug Discovery Today. 9: S19-26
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