José Leal Prado de Carvalho, M.D., Ph.D.

Affiliations: 
1940-1987 Departamento de Bioquímica Universidade Federal de São Paulo - Escola Paulista de Medicina 
Area:
Biochemistry
Website:
http://www2.unifesp.br/dbioq/portal/historico/historico
Google:
"José de Carvalho"
Bio:

José Leal Prado de Carvalho, Brazilian biochemist (Alfenas, Minas Gerais State 08 September 1918 – São Paulo 11 January 1987)

Authored most of his works joint to his wife biochemist Eline Michelet Sant’Anna Prado (1921-2007).
ACHIEVEMENTS
Discovered metacorticoid hypertension independently of S. Fridman; Demonstrated the tissue conversion of angiotensin I to angiotensin II, the first demonstration of the presence of converting enzymes in tissues with E. A. Carlini & Z. Picarelli. Pharmacological activity of hypertension I and its conversion into hypertension II. Bull. Soc. Chim. Biol. 40:1825-34, 1958

Performed important studies on metabolism and release of kinins;
First described clostripain, a kinin from bacterial origin;
First obtained urinary kallikrein in pure form;
Isolated and characterized glycyl-bradykinin from wasp venom;
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Mean distance: 10.09
 
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