jian zhang

Shanghai Jiao Tong University School of Medicine 
Molecular Design
"jian zhang"

Molecular Design Laboratory
Institute of Medical Science
Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education
School of Medicine
Shanghai Jiaotong University
Room 1006&1008, 280 Chongqing Road, Building 2, Shanghai 20025, China
Tel: 86-21-63846590-776922
Fax: 86-21-64154900
E-mail: jian.zhang@sjtu.edu.cn & jzhang.dr@gmail.com

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Shang JL, Ning SB, Chen YY, et al. (2020) MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer. Acta Pharmacologica Sinica
Zhang X, Shi S, Su Y, et al. (2020) Suramin and NF449 are IP5K inhibitors that disrupt IP6-mediated regulation of cullin RING ligase and sensitize cancer cells to MLN4924/pevonedistat. The Journal of Biological Chemistry
Shang J, Zhu Z, Chen Y, et al. (2020) Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D in colorectal cancer. Theranostics. 10: 5845-5864
Qin J, Shen X, Zhang J, et al. (2020) Allosteric inhibitors of the STAT3 signaling pathway. European Journal of Medicinal Chemistry. 190: 112122
Lu S, Chen Y, Wei J, et al. (2020) Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators Acta Pharmaceutica Sinica B
Huang K, Liang Q, Zhou Y, et al. (2019) A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer. Cell Metabolism
Wang L, Zhang L, Li L, et al. (2019) Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer. Science Advances. 5: eaax2277
Yao H, Tang H, Zhang Y, et al. (2019) DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma. Cancer Letters
Xu X, Chen Y, Fu Q, et al. (2019) The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 361-374
Yang X, Deng M, Zhang X, et al. (2018) Design, Synthesis, and Biological Evaluation of Thieno[3,2-d]pyrimidine Derivatives as Potential Simplified Phosphatidylinositol 3-Kinase alpha (PI3Kα) inhibitors. Chemical Biology & Drug Design
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