David J. Vocadlo, Ph.D.

Affiliations: 
2002 University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
enzyme mechanisms, protein structure/function relationships, enzyme inhibitor design/synthesis and protein engineering
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"David Vocadlo"
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SNBCP

Parents

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Stephen G. Withers grad student 2002 UBC
 (The catalytic mechanism of retaining beta -glycosidases.)

Children

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Samy Cecioni grad student
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Publications

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Mangat CS, Vadlamani G, Holicek V, et al. (2019) Molecular basis for the potent inhibition of the emerging carbapenemase VCC-1 by avibactam. Antimicrobial Agents and Chemotherapy
Ho LA, Winogrodzki JL, Debowski AW, et al. (2018) A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa. Chemical Communications (Cambridge, England)
Vadlamani G, Stubbs KA, Désiré J, et al. (2017) Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance. Protein Science : a Publication of the Protein Society
Roth C, Chan S, Offen WA, et al. (2017) Structural and functional insight into human O-GlcNAcase. Nature Chemical Biology
Perley-Robertson GE, Yadav AK, Winogrodzki JL, et al. (2016) A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance. Acs Chemical Biology
Noach I, Pluvinage B, Laurie C, et al. (2016) The details of glycolipid glycan hydrolysis by the structural analysis of a family 123 glycoside hydrolase from Clostridium perfringens. Journal of Molecular Biology
Hattie M, Cekic N, Debowski AW, et al. (2016) Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases. Organic & Biomolecular Chemistry
Bergeron-Brlek M, Goodwin-Tindall J, Cekic N, et al. (2015) A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors. Angewandte Chemie (International Ed. in English)
Gregg KJ, Suits MD, Deng L, et al. (2015) Structural analysis of a family 101 glycoside hydrolase in complex with carbohydrates reveals insights into its mechanism. The Journal of Biological Chemistry
Zhu Y, Liu TW, Cecioni S, et al. (2015) O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains. Nature Chemical Biology. 11: 319-25
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