Carl S. Rye, Ph.D.

Affiliations: 
2002 University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
enzyme mechanisms, protein structure/function relationships, enzyme inhibitor design/synthesis and protein engineering
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"Carl Rye"
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Stephen G. Withers grad student 2002 UBC
 (Mechanistic studies of chondroitin AC lyase from Flavobacterium heparinum.)
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Publications

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Robinson CW, Rye CS, Chessum NE, et al. (2015) A model β-sheet interaction and thermodynamic analysis of β-strand mimetics. Organic & Biomolecular Chemistry. 13: 7402-7
Koehler MF, Bergeron P, Choo EF, et al. (2014) Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. Acs Medicinal Chemistry Letters. 5: 662-7
Rye CS, Baell JB, Street I. (2007) Synthesis, reactivity and applications of 1-fluoroalkyl carboxylates: novel synthetic substrates for esterases and lipases Tetrahedron. 63: 3306-3311
Rye CS, Matte A, Cygler M, et al. (2006) An atypical approach identifies TYR234 as the key base catalyst in chondroitin AC lyase. Chembiochem : a European Journal of Chemical Biology. 7: 631-7
Rye CS, Baell JB. (2005) Phosphate isosteres in medicinal chemistry. Current Medicinal Chemistry. 12: 3127-41
Rye CS, Withers SG. (2004) The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases. Carbohydrate Research. 339: 699-703
Becker NSC, Bennett DM, Bolto BA, et al. (2004) Detection of polyelectrolytes at trace levels in water by fluorescent tagging Reactive and Functional Polymers. 60: 183-193
Rye CS, Withers SG. (2002) Development of an assay and determination of kinetic parameters for chondroitin AC lyase using defined synthetic substrates. Analytical Biochemistry. 308: 77-82
Rye CS, Withers SG. (2002) Elucidation of the mechanism of polysaccharide cleavage by chondroitin AC lyase from Flavobacterium heparinum. Journal of the American Chemical Society. 124: 9756-67
Rye CS, Withers SG. (2002) Synthesis and evaluation of potential inhibitors of chondroitin AC lyase from Flavobacterium heparinum. The Journal of Organic Chemistry. 67: 4505-12
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