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Alex Praseuth, Ph.D.

Affiliations: 
2008 Pharmaceutical Sciences University of Southern California, Los Angeles, CA, United States 
Area:
Natural Product Biosynthesis
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"Alex Praseuth"
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Clay C.C. Wang grad student 2008 USC
 (Assembling NRPS modules in Escherichia coli to establish a platform for rational design of biologically active compounds.)

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Publications

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Nakazawa T, Ishiuchi K, Praseuth A, et al. (2012) Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce a novel polyketide. Chembiochem : a European Journal of Chemical Biology. 13: 855-61
Saruwatari T, Praseuth AP, Sato M, et al. (2011) A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases. The Journal of Antibiotics. 64: 9-17
Watanabe K, Hotta K, Praseuth AP, et al. (2009) Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. Chembiochem : a European Journal of Chemical Biology. 10: 1965-8
Watanabe K, Hotta K, Nakaya M, et al. (2009) Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. Journal of the American Chemical Society. 131: 9347-53
Watanabe K, Praseuth AP, Praseuth MB, et al. (2009) Chapter 15. Plasmid-borne gene cluster assemblage and heterologous biosynthesis of nonribosomal peptides in Escherichia coli. Methods in Enzymology. 458: 379-99
Praseuth AP, Wang CC, Watanabe K, et al. (2008) Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. Biotechnology Progress. 24: 1226-31
Chiang YM, Szewczyk E, Nayak T, et al. (2008) Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chemistry & Biology. 15: 527-32
Praseuth AP, Praseuth MB, Oguri H, et al. (2008) Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture. Biotechnology Progress. 24: 134-9
Watanabe K, Praseuth AP, Wang CC. (2007) A comprehensive and engaging overview of the type III family of polyketide synthases. Current Opinion in Chemical Biology. 11: 279-86
Watanabe K, Hotta K, Praseuth AP, et al. (2006) Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nature Chemical Biology. 2: 423-8
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