Sundari K. Rallapalli, Ph.D.

Affiliations: 
2012 Chemistry University of Wisconsin-Milwaukee, Milwaukee, WI 
Area:
Alkaloid total synthesis
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James M. Cook grad student 2012 UW-Milwaukee
 (Part I. The first enantiospecific, stereospecific total synthesis of the indole alkaloid ervincidine Part II. The synthesis of alpha 5 subtype selective ligands for GABA(A) /benzodiazepine receptors.)
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Publications

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Fischer BD, Platt DM, Rallapalli SK, et al. (2015) Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis. Drug and Alcohol Dependence
Hackett CS, Quigley DA, Wong RA, et al. (2014) Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Reports. 9: 1034-46
Rallapalli SK, Namjoshi OA, Tiruveedhula VV, et al. (2014) Stereospecific total synthesis of the indole alkaloid ervincidine. Establishment of the C-6 hydroxyl stereochemistry. The Journal of Organic Chemistry. 79: 3776-80
Rae CD, Davidson JE, Maher AD, et al. (2014) Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations. Journal of Neurochemistry. 129: 304-14
Sengupta S, Weeraratne SD, Sun H, et al. (2014) α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. Acta Neuropathologica. 127: 593-603
Soto PL, Ator NA, Rallapalli SK, et al. (2013) Allosteric modulation of GABA(A) receptor subtypes:effects on visual recognition and visuospatial working memory in rhesus monkeys [corrected]. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2315-25
Joksimović S, Varagic Z, Kovačević J, et al. (2013) Insights into functional pharmacology of α₁ GABA(A) receptors: how much does partial activation at the benzodiazepine site matter? Psychopharmacology. 230: 113-23
Varagic Z, Ramerstorfer J, Huang S, et al. (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. British Journal of Pharmacology. 169: 384-99
Varagic Z, Wimmer L, Schnürch M, et al. (2013) Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. British Journal of Pharmacology. 169: 371-83
Makaron L, Moran CA, Namjoshi O, et al. (2013) Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys. Pharmacology, Biochemistry, and Behavior. 104: 62-8
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