Brian T. Chamberlain, Ph.D.

Affiliations: 
2012 Chemistry University of Southern California, Los Angeles, CA, United States 
Area:
organophosphorus, bioorganic and medicinal chemistry
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Charles E. McKenna grad student 2012 USC
 (Deoxynucleotide analog probes and model compounds for studying DNA polymerase structure and mechanism: Synthesis and evaluation of alkyl-, azido-, and halomethylene bisphosphonate-substituted triphosphates.)
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Publications

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Haratipour P, Minard C, Nakhjiri M, et al. (2020) Completing the β,γ-CXY-dNTP Stereochemical Probe Toolkit: Synthetic Access to the dCTP Diastereomers and P and F NMR Correlations with Absolute Configurations. The Journal of Organic Chemistry
Oertell K, Chamberlain BT, Wu Y, et al. (2014) Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration. Biochemistry. 53: 1842-8
Chamberlain BT, Batra VK, Beard WA, et al. (2012) Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β. Chembiochem : a European Journal of Chemical Biology. 13: 528-30
Chamberlain BT, Batra VK, Beard WA, et al. (2012) Stereospecific Formation of a Ternary Complex of (S)-alpha, beta-Fluoromethylene-dATP with DNA Pol beta. Chembiochem. 13: 528-530
Chamberlain BT, Osuna J, Kashemirov BA, et al. (2011) Synthesis and sensing of bisphosphonophosphate alkyl monoesters: A novel class of compounds for the study of nucleoside 5'-triphosphate chemistry. Phosphorus, Sulfur, and Silicon and the Related Elements. 186: 966-967
Chamberlain BT, Upton TG, Kashemirov BA, et al. (2011) α-Azido bisphosphonates: synthesis and nucleotide analogues. The Journal of Organic Chemistry. 76: 5132-6
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