Ryan T. Cirz, Ph.D.
Affiliations: | 2007 | Scripps Research Institute, La Jolla, La Jolla, CA, United States |
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| Prasad NK, Seiple IB, Cirz RT, et al. (2022) Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020. Antimicrobial Agents and Chemotherapy. e0005422 |
| Bulman ZP, Cirz R, Hildebrandt D, et al. (2020) Unraveling the gentamicin drug product complexity reveals variation in microbiological activities and nephrotoxicity. Antimicrobial Agents and Chemotherapy |
| Krause KM, Haglund CM, Hebner C, et al. (2019) Potent LpxC Inhibitors with Activity Against Multi-Drug Resistant . Antimicrobial Agents and Chemotherapy |
| Andrews LD, Kane TR, Dozzo P, et al. (2019) Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase. Journal of Medicinal Chemistry |
| Cohen F, Aggen JB, Andrews LD, et al. (2019) -Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety. Chemmedchem |
| Wagman AS, Cirz R, McEnroe G, et al. (2017) Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones. Chemmedchem |
| Laponogov I, Pan XS, Veselkov DA, et al. (2016) Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones. Open Biology. 6 |
| Heine HS, Chuvala L, Riggins R, et al. (2016) Natural History of Francisella tularensis in Aerosol-Challenged BALB/c Mice. Antimicrobial Agents and Chemotherapy. 60: 1834-40 |
| Drusano GL, Liu W, Fikes S, et al. (2014) Interaction of drug- and granulocyte-mediated killing of Pseudomonas aeruginosa in a murine pneumonia model. The Journal of Infectious Diseases. 210: 1319-24 |
| Roberts TC, Smith PA, Cirz RT, et al. (2007) Structural and initial biological analysis of synthetic arylomycin A2. Journal of the American Chemical Society. 129: 15830-8 |