Keisuke Hirai, PhD, Osaka University

Takeda Chemical Industries 
Neurodegenerative diseases
"Keisuke Hirai"

Mean distance: 16.9 (cluster 28)
Cross-listing: Neurotree - Neuropathology Tree


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George Perry post-doc 1997-1998 Case Western
Mark Anthony Smith post-doc 1997-1998 Case Western (Neurotree)
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Swarup V, Hinz FI, Rexach JE, et al. (2018) Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nature Medicine
Ishigaki H, Itou H, Takeshima T, et al. (2013) [Henoch-Schönlein purpura developed after radical cystectomy]. Hinyokika Kiyo. Acta Urologica Japonica. 59: 663-7
Fukumoto H, Takahashi H, Tarui N, et al. (2010) A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11157-66
Nunomura A, Honda K, Takeda A, et al. (2006) Oxidative damage to RNA in neurodegenerative diseases. Journal of Biomedicine & Biotechnology. 2006: 82323
Zhu X, Perry G, Moreira PI, et al. (2006) Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease. Journal of Alzheimer's Disease : Jad. 9: 147-53
Tateyama M, Takeda A, Onodera Y, et al. (2003) Oxidative stress and predominant Abeta42(43) deposition in myopathies with rimmed vacuoles. Acta Neuropathologica. 105: 581-5
Perry G, Nunomura A, Cash AD, et al. (2002) Reactive oxygen: its sources and significance in Alzheimer disease. Journal of Neural Transmission. Supplementum. 69-75
Perry G, Nunomura A, Hirai K, et al. (2002) Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biology & Medicine. 33: 1475-9
Castellani R, Hirai K, Aliev G, et al. (2002) Role of mitochondrial dysfunction in Alzheimer's disease. Journal of Neuroscience Research. 70: 357-60
Kawanaka Y, Kobayashi K, Kusuda S, et al. (2002) Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines. Bioorganic & Medicinal Chemistry Letters. 12: 2291-4
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