Bruno D. Chapsal, Ph.D.

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2005 Stony Brook University, Stony Brook, NY, United States 
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"Bruno Chapsal"
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Iwao Ojima grad student 2005 SUNY Stony Brook
 (Studies and synthetic applications of transition metal catalyzed reactions.)
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Publications

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Ghosh AK, Chapsal BD. (2013) Design of the anti-HIV protease inhibitor darunavir Introduction to Biological and Small Molecule Drug Research and Development. 355-384
Ghosh AK, Chapsal BD, Steffey M, et al. (2012) Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2308-11
Ghosh AK, Chapsal BD, Parham GL, et al. (2011) Design of HIV-1 protease inhibitors with C3-substituted hexahydrocyclopentafuranyl urethanes as P2-ligands: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. Journal of Medicinal Chemistry. 54: 5890-901
Ide K, Aoki M, Amano M, et al. (2011) Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants. Antimicrobial Agents and Chemotherapy. 55: 1717-27
Ghosh AK, Chapsal BD, Baldridge A, et al. (2011) Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation. Journal of Medicinal Chemistry. 54: 622-34
Ghosh AK, Chapsal BD, Baldridge A, et al. (2008) Design and synthesis of stereochemically defined novel spirocyclic P2-ligands for HIV-1 protease inhibitors. Organic Letters. 10: 5135-8
Ghosh AK, Chapsal BD, Weber IT, et al. (2008) Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance. Accounts of Chemical Research. 41: 78-86
Chapsal BD, Ojima I. (2006) Total synthesis of enantiopure (+)-gamma-lycorane using highly efficient Pd-catalyzed asymmetric allylic alkylation. Organic Letters. 8: 1395-8
Chapsal BD, Hua Z, Ojima I. (2006) Catalytic asymmetric transformations with fine-tunable biphenol-based monodentate ligands Tetrahedron Asymmetry. 17: 642-657
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