John J. Tesmer
Affiliations: | Cell and molecular biology | University of Texas at Austin, Austin, Texas, U.S.A. |
Area:
Molecular Biology, Biochemistry, General BiophysicsGoogle:
"John Tesmer"Parents
Sign in to add mentor| Janet L. Smith | grad student | 1990-1995 | Purdue | |
| (GMP Synthetase from Escherichia Coli at 2.2 Å Resolution.) | ||||
| Stephen R. Sprang | post-doc | 1996-1999 | UT Southwestern (Chemistry Tree) | |
| (Crystallographic studies of heterotrimeric G proteins and their complexes with effectors and regulatory proteins.) | ||||
Children
Sign in to add trainee| Romana Kristelly | grad student | 2004 | UT Austin |
| David T. Lodowski | grad student | 2004 | UT Austin |
| Angeline Lyon | post-doc | 2009-2014 | University of Michigan (Chemistry Tree) |
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Publications
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| Cash JN, Sharma PV, Tesmer JJ. (2019) Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3 Journal of Structural Biology: X. 1: 100001 |
| Bouley R, Waldschmidt HV, Cato MC, et al. (2017) Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Molecular Pharmacology |
| Cash JN, Davis EM, Tesmer JJ. (2016) Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure (London, England : 1993) |
| Tesmer JJ. (2016) Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes. Nature Reviews. Molecular Cell Biology |
| Yang P, Homan KT, Li Y, et al. (2016) Effect of Lipid Composition on Membrane Orientation of the G protein-coupled Receptor Kinase 2-Gβ1γ2 Complex. Biochemistry |
| Waldschmidt HV, Homan KT, Cruz-Rodriguez O, et al. (2016) Structure-Based Design, Synthesis and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. Journal of Medicinal Chemistry |
| Taylor VG, Bommarito PA, Tesmer JJ. (2016) Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: Molecular Basis for Gα Selectivity. The Journal of Biological Chemistry |
| Taylor VG, Bommarito PA, Tesmer JJ. (2016) Structure of the Regulator of G Protein Signaling 8 (RGS8)-G alpha q Complex: MOLECULAR BASIS FOR G alpha SELECTIVITY. Journal of Biological Chemistry. 291: 5138-5145 |
| Inagaki S, Ghirlando R, Vishnivetskiy SA, et al. (2015) G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro. Biochemistry. 54: 4320-9 |
| Homan KT, Waldschmidt HV, Glukhova A, et al. (2015) Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. The Journal of Biological Chemistry |