R Bruce Dunlap

Affiliations: 
University of South Carolina, Columbia, SC 
Area:
Biochemistry
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"R Dunlap"
Mean distance: 9953.25
 
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Publications

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Felder T, Dunlap RB, Dix D, et al. (2002) Differences in natural ligand and fluoropyrimidine binding to human thymidylate synthase identified by transient-state spectroscopic and continuous variation methods. Biochimica Et Biophysica Acta. 1597: 149-56
Phan J, Koli S, Minor W, et al. (2001) Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug. Biochemistry. 40: 1897-902
Phan J, Steadman DJ, Koli S, et al. (2001) Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. The Journal of Biological Chemistry. 276: 14170-7
Radfar R, Leaphart A, Brewer JM, et al. (2000) Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica. Biochemistry. 39: 14481-6
Michalczyk R, Schmidt JG, Moody E, et al. (2000) Unusual C-H small middle dot small middle dot small middle dotSe=C Interactions in Aldols of Chiral N-Acyl Selones Detected by Gradient-Selected (1)H-(77)Se HMQC NMR Spectroscopy and X-ray Crystallography This work was supported by the Los Alamos National Laboratory Directed Research and Development Fund (grant XAB2). We thank Dr. Judith Gallucci (Department of Chemistry, Ohio State University) for obtaining the X-ray structures of 1 and 3, and Dr. Charles Campana (Bruker Analytical X-ray Systems in Madison, WI) for obtaining the X-ray structure of 2. Angewandte Chemie (International Ed. in English). 39: 3067-3070
Phan J, Mahdavian E, Nivens MC, et al. (2000) Catalytic cysteine of thymidylate synthase is activated upon substrate binding. Biochemistry. 39: 6969-78
Radfar R, Shin R, Sheldrick GM, et al. (2000) The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica. Biochemistry. 39: 3920-6
Li Z, Wu R, Michalczyk R, et al. (2000) Stereoselectivity in aldol reactions of chiral N-acyl selones Journal of the American Chemical Society. 122: 386-387
Mahdavian E, Spencer HT, Dunlap RB. (1999) Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4. Archives of Biochemistry and Biophysics. 368: 257-64
Steadman DJ, Spencer HT, Dunlap RB, et al. (1999) Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes. Biochemistry. 38: 5582-7
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