David L. Pompliano

Apple Tree Partners 
drug discovery, antimicrobials, enzymology, natural products, microbiome
"David Pompliano"
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Kulp JL, Kulp JL, Pompliano DL, et al. (2011) Diverse fragment clustering and water exclusion identify protein hot spots. Journal of the American Chemical Society. 133: 10740-3
Angulo-Barturen I, Jiménez-Díaz MB, Mulet T, et al. (2008) A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. Plos One. 3: e2252
Bradley JS, Guidos R, Baragona S, et al. (2007) Anti-infective research and development--problems, challenges, and solutions. The Lancet. Infectious Diseases. 7: 68-78
Payne DJ, Gwynn MN, Holmes DJ, et al. (2007) Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nature Reviews. Drug Discovery. 6: 29-40
Copeland RA, Pompliano DL, Meek TD. (2006) Drug-target residence time and its implications for lead optimization. Nature Reviews. Drug Discovery. 5: 730-9
Triolo TA, Chabin RM, Pompliano DL. (2004) Cloning, expression and characterization of the Streptococcus pyogenes murE gene encoding a UDP-MurNAc-L-alanyl-D-glutamate: L-lysine ligase Enzyme and Microbial Technology. 35: 300-308
Bobkova EV, Yan YP, Jordan DB, et al. (2003) Catalytic properties of mutant 23 S ribosomes resistant to oxazolidinones. The Journal of Biological Chemistry. 278: 9802-7
Barbosa MD, Lin S, Markwalder JA, et al. (2002) Regulated expression of the Escherichia coli lepB gene as a tool for cellular testing of antimicrobial compounds that inhibit signal peptidase I in vitro. Antimicrobial Agents and Chemotherapy. 46: 3549-54
Barbosa MD, Ross HO, Hillman MC, et al. (2002) A multitarget assay for inhibitors of membrane-associated steps of peptidoglycan biosynthesis. Analytical Biochemistry. 306: 17-22
Zhang Y, Yang F, Kao YC, et al. (2002) Homogenous assays for Escherichia coli DnaB-stimulated DnaG primase and DnaB helicase and their use in screening for chemical inhibitors. Analytical Biochemistry. 304: 174-9
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