Sachin Kale, Ph.D.

Affiliations: 
2008 Rutgers The State University of New Jersey - Newark, United States 
Area:
Biochemistry, General Biophysics
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"Sachin Kale"
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Frank Jordan grad student 2008 Rutgers, Newark
 (Characterization of the dynamics in the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex.)
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Publications

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Song J, Park YH, Nemeria NS, et al. (2010) Nuclear magnetic resonance evidence for the role of the flexible regions of the E1 component of the pyruvate dehydrogenase complex from gram-negative bacteria. The Journal of Biological Chemistry. 285: 4680-94
Jordan F, Arjunan P, Kale S, et al. (2009) Multiple roles of mobile active center loops in the E1 component of the Escherichia coli pyruvate dehydrogenase complex - Linkage of protein dynamics to catalysis. Journal of Molecular Catalysis. B, Enzymatic. 61: 14-22
Kale S, Jordan F. (2009) Conformational ensemble modulates cooperativity in the rate-determining catalytic step in the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex. The Journal of Biological Chemistry. 284: 33122-9
Kale S, Ulas G, Song J, et al. (2008) Efficient coupling of catalysis and dynamics in the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex. Proceedings of the National Academy of Sciences of the United States of America. 105: 1158-63
Kale S, Arjunan P, Furey W, et al. (2007) A dynamic loop at the active center of the Escherichia coli pyruvate dehydrogenase complex E1 component modulates substrate utilization and chemical communication with the E2 component. The Journal of Biological Chemistry. 282: 28106-16
Kale S, Jordan F. (2007) Interaction of Residues Aspartate 549 and Arginine 404 Modulates Active Site Accessibility and Intersubunit Communication in the E1 Subunit of Escherichia coli Pyruvate Dehydrogenase Multienzyme Complex The Faseb Journal. 21
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