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Erkan Karakas, Ph.D.

Affiliations: 
2006 Stony Brook University, Stony Brook, NY, United States 
 2007-2016 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
 2016- Vanderbilt University, Nashville, TN 
Area:
Molecular Biology, Pharmacology
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"Erkan Karakas"
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Parents

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Daniel F. Bogenhagen grad student 2006 SUNY Stony Brook
 (Structural characterization of key enzymes in eubacterial nucleotide excision repair and the physiologically essential enzyme sulfite oxidase.)
Caroline Kisker grad student 2006 SUNY Stony Brook
 (Structural characterization of key enzymes in eubacterial nucleotide excision repair and the physiologically essential enzyme sulfite oxidase.)
Hiro Furukawa post-doc 2007-2016 CSHL

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Publications

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Azumaya CM, Linton EA, Risener CJ, et al. (2020) Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist. The Journal of Biological Chemistry
Regan MC, Grant T, McDaniel MJ, et al. (2018) Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron
Romero-Hernandez A, Simorowski N, Karakas E, et al. (2016) Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain. Neuron
Tajima N, Karakas E, Grant T, et al. (2016) Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Nature
Karakas E, Regan MC, Furukawa H. (2015) Emerging structural insights into the function of ionotropic glutamate receptors. Trends in Biochemical Sciences. 40: 328-37
Khatri A, Burger PB, Swanger SA, et al. (2014) Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Molecular Pharmacology. 86: 548-60
Karakas E, Furukawa H. (2014) Crystal structure of a heterotetrameric NMDA receptor ion channel. Science (New York, N.Y.). 344: 992-7
Burger PB, Yuan H, Karakas E, et al. (2012) Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. Molecular Pharmacology. 82: 344-59
Karakas E, Simorowski N, Furukawa H. (2011) Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature. 475: 249-53
Karakas E, Simorowski N, Furukawa H. (2010) Structural Insights into Allosteric Modulation of NMDA Receptors Through the Amino-Terminal Domain Biophysical Journal. 98: 609a
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