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Fagen Zhang, Ph.D.

Affiliations: 
2001 University of Illinois at Chicago, Health Sciences Center, Chicago, IL 60612, United States 
Area:
Toxicology, Pharmacology, Organic Chemistry
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"Fagen Zhang"
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Judy L. Bolton grad student 2001 University of Illinois at Chicago, Health Sciences Center
 (Synthesis and reactivity of potential carcinogenic catechol metabolites from equine estrogens and tamoxifen.)

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Publications

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Zhang F, Lowe ER, Rick DL, et al. (2011) In vitro metabolism, glutathione conjugation, and CYP isoform specificity of epoxidation of 4-vinylphenol. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 6-23
Yu L, Liu H, Li W, et al. (2004) Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones. Chemical Research in Toxicology. 17: 879-88
Liu X, Zhang F, Liu H, et al. (2003) Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin. Chemical Research in Toxicology. 16: 741-9
Johnson BM, Qiu SX, Zhang S, et al. (2003) Identification of novel electrophilic metabolites of piper methysticum Forst (Kava). Chemical Research in Toxicology. 16: 733-40
Zhang F, Swanson SM, van Breemen RB, et al. (2001) Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. Chemical Research in Toxicology. 14: 1654-9
Yao D, Zhang F, Yu L, et al. (2001) Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones. Chemical Research in Toxicology. 14: 1643-53
Zhang F, Yao D, Hua Y, et al. (2001) Synthesis and reactivity of the catechol metabolites from the equine estrogen, 8,9-dehydroestrone. Chemical Research in Toxicology. 14: 754-63
Spink DC, Zhang F, Hussain MM, et al. (2001) Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells. Chemical Research in Toxicology. 14: 572-81
Hua Y, Wainhaus SB, Yang Y, et al. (2001) Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides. Journal of the American Society For Mass Spectrometry. 12: 80-7
Chen Y, Liu X, Pisha E, et al. (2000) A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chemical Research in Toxicology. 13: 342-50
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