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Zhican Wang, Ph.D.

Affiliations: 
2009 University of Illinois at Chicago, Health Sciences Center, Chicago, IL 60612, United States 
Area:
Toxicology, Biochemistry
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"Zhican Wang"
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Judy L. Bolton grad student 2009 University of Illinois at Chicago, Health Sciences Center
 (Activation and genotoxic consequences of the PremarinRTM equine estrogen metabolites to reactive quinones.)

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Publications

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Tang X, Di X, Zhong Z, et al. (2016) In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes. Journal of Pharmaceutical and Biomedical Analysis. 128: 98-105
He LL, Liu XP, Wang YX, et al. (2016) Sonochemical degradation of methyl orange in the presence of Bi2WO6: Effect of operating parameters and the generated reactive oxygen species Ultrasonics Sonochemistry. 33: 90-98
Locke AE, Kahali B, Berndt SI, et al. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature. 518: 197-206
Wood AR, Esko T, Yang J, et al. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 46: 1173-86
Randall JC, Winkler TW, Kutalik Z, et al. (2013) Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. Plos Genetics. 9: e1003500
Peng KW, Chang M, Wang YT, et al. (2010) Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chemical Research in Toxicology. 23: 1374-83
Wang Z, Chandrasena ER, Yuan Y, et al. (2010) Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. Chemical Research in Toxicology. 23: 1365-73
Peng KW, Wang H, Qin Z, et al. (2009) Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells. Acs Chemical Biology. 4: 1039-49
Wang Z, Edirisinghe P, Sohn J, et al. (2009) Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells. Chemical Research in Toxicology. 22: 1129-36
Wang Z, Wijewickrama GT, Peng KW, et al. (2009) Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. The Journal of Biological Chemistry. 284: 8633-42
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