William G. Dunphy
Affiliations: | California Institute of Technology, Pasadena, CA |
Area:
Cell Biology, Genetics, BiochemistryGoogle:
"William Dunphy"Mean distance: 39813
Parents
Sign in to add mentor| James E. Rothman | grad student | Caltech | |
| John Newport | post-doc | Caltech (Cell Biology Tree) |
Children
Sign in to add trainee| Daniel A. Gold | grad student | 2010 | Caltech |
| Juan S. Ramirez-Lugo | grad student | 2010 | Caltech |
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Publications
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| Kumagai A, Dunphy WG. (2020) Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication. Cell Reports. 32: 108178 |
| Lim DC, Joukov V, Rettenmaier TJ, et al. (2020) Redox priming promotes Aurora A activation during mitosis. Science Signaling. 13 |
| Lyu K, Kumagai A, Dunphy WG. (2019) RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR. Cell Cycle (Georgetown, Tex.). 1-16 |
| Kumagai A, Dunphy WG. (2017) MTBP, the Partner of Treslin, Contains a Novel DNA-Binding Domain, That Is Essential for Proper Initiation of DNA Replication. Molecular Biology of the Cell |
| Mu R, Tat J, Zamudio R, et al. (2017) CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin. Molecular and Cellular Biology |
| Ryu H, Yoshida MM, Sridharan V, et al. (2015) SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin. Cell Cycle (Georgetown, Tex.). 14: 2777-84 |
| Guo C, Kumagai A, Schlacher K, et al. (2015) Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Molecular Cell. 57: 492-505 |
| Lee J, Dunphy WG. (2013) The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Molecular Biology of the Cell. 24: 1343-53 |
| Kumar S, Yoo HY, Kumagai A, et al. (2012) Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. Cell Cycle (Georgetown, Tex.). 11: 1183-94 |
| Meng Z, Capalbo L, Glover DM, et al. (2011) Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Molecular Biology of the Cell. 22: 2834-47 |