William G. Dunphy

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Cell Biology, Genetics, Biochemistry
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"William Dunphy"
Mean distance: 39813
 

Parents

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James E. Rothman grad student Caltech
John Newport post-doc Caltech (Cell Biology Tree)

Children

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Daniel A. Gold grad student 2010 Caltech
Juan S. Ramirez-Lugo grad student 2010 Caltech
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Publications

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Kumagai A, Dunphy WG. (2020) Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication. Cell Reports. 32: 108178
Lim DC, Joukov V, Rettenmaier TJ, et al. (2020) Redox priming promotes Aurora A activation during mitosis. Science Signaling. 13
Lyu K, Kumagai A, Dunphy WG. (2019) RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR. Cell Cycle (Georgetown, Tex.). 1-16
Kumagai A, Dunphy WG. (2017) MTBP, the Partner of Treslin, Contains a Novel DNA-Binding Domain, That Is Essential for Proper Initiation of DNA Replication. Molecular Biology of the Cell
Mu R, Tat J, Zamudio R, et al. (2017) CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin. Molecular and Cellular Biology
Ryu H, Yoshida MM, Sridharan V, et al. (2015) SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin. Cell Cycle (Georgetown, Tex.). 14: 2777-84
Guo C, Kumagai A, Schlacher K, et al. (2015) Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Molecular Cell. 57: 492-505
Lee J, Dunphy WG. (2013) The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Molecular Biology of the Cell. 24: 1343-53
Kumar S, Yoo HY, Kumagai A, et al. (2012) Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. Cell Cycle (Georgetown, Tex.). 11: 1183-94
Meng Z, Capalbo L, Glover DM, et al. (2011) Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Molecular Biology of the Cell. 22: 2834-47
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