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Myron K. Jacobson

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
Biochemistry
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"Myron Jacobson"
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Rafael Alvarez-Gonzalez grad student 1980-1985 University of North Texas (Cell Biology Tree)
David W. Koh grad student 2001 University of Kentucky

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Publications

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Alvarez-Gonzalez R, Jacobson MK. (2011) Quantification of poly(ADP-ribose) in vitro: determination of the ADP-ribose chain length and branching pattern. Methods in Molecular Biology (Clifton, N.J.). 780: 35-46
Steffen JD, Coyle DL, Damodaran K, et al. (2011) Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). Journal of Medicinal Chemistry. 54: 5403-13
Botta D, Jacobson MK. (2010) Identification of a regulatory segment of poly(ADP-ribose) glycohydrolase. Biochemistry. 49: 7674-82
Patel CN, Koh DW, Jacobson MK, et al. (2005) Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain. The Biochemical Journal. 388: 493-500
Meyer-Ficca ML, Meyer RG, Coyle DL, et al. (2004) Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments. Experimental Cell Research. 297: 521-32
Koh DW, Coyle DL, Mehta N, et al. (2003) SAR analysis of adenosine diphosphate (hydroxymethyl)pyrrolidinediol inhibition of poly(ADP-ribose) glycohydrolase. Journal of Medicinal Chemistry. 46: 4322-32
Koh DW, Patel CN, Ramsinghani S, et al. (2003) Identification of an inhibitor binding site of poly(ADP-ribose) glycohydrolase. Biochemistry. 42: 4855-63
Rutherford TJ, Wilkie J, Vu CQ, et al. (2001) NMR studies and semi-empirical energy calculations for cyclic ADP-ribose. Nucleosides, Nucleotides & Nucleic Acids. 20: 1485-95
Wondrak GT, Cervantes-Laurean D, Jacobson EL, et al. (2000) Histone carbonylation in vivo and in vitro Biochemical Journal. 351: 769-777
Wondrak GT, Varadarajan S, Butterfield DA, et al. (2000) Formation of a protein-bound pyrazinium free radical cation during glycation of histone H1. Free Radical Biology & Medicine. 29: 557-67
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