John Tainer

Scripps Research Institute, La Jolla, La Jolla, CA, United States 
"John Tainer"
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Nguyen MT, Moiani D, Ahmed Z, et al. (2021) An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation. Progress in Biophysics and Molecular Biology
Brosey CA, Houl JH, Katsonis P, et al. (2021) Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Progress in Biophysics and Molecular Biology
Hammel M, Rashid I, Sverzhinsky A, et al. (2020) An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex. Nucleic Acids Research
Wilson DM, Deacon AM, Duncton MAJ, et al. (2020) Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Progress in Biophysics and Molecular Biology
Lees-Miller JP, Cobban A, Katsonis P, et al. (2020) Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Progress in Biophysics and Molecular Biology
Tsutakawa SE, Tsai CL, Yan C, et al. (2020) Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair. Dna Repair. 96: 102972
Hammel M, Rosenberg DJ, Bierma J, et al. (2020) Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM. Progress in Biophysics and Molecular Biology
Eckelmann BJ, Bacolla A, Wang H, et al. (2020) XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells. Nar Cancer. 2: zcaa013
Tsutakawa SE, Sarker AH, Ng C, et al. (2020) Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations. Proceedings of the National Academy of Sciences of the United States of America
Houl JH, Ye Z, Brosey CA, et al. (2019) Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nature Communications. 10: 5654
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