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Aming Zhang, Ph.D.

Affiliations: 
2011 University of Virginia, Charlottesville, VA 
Area:
Chemical Engineering
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"Aming Zhang"
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Erik J. Fernandez grad student 2011 UVA
 (Structural mechanism of stress-induced protein aggregation revealed by hydrogen/deuterium exchange mass spectrometry (HX-MS).)

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Publications

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Weiss WF, Zhang A, Ivanova MI, et al. (2014) Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation. Biophysical Chemistry. 185: 79-87
Zhang Z, Zhang A, Xiao G. (2012) Improved protein hydrogen/deuterium exchange mass spectrometry platform with fully automated data processing. Analytical Chemistry. 84: 4942-9
Zhang A, Singh SK, Shirts MR, et al. (2012) Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange. Pharmaceutical Research. 29: 236-50
Zhang A, Qi W, Singh SK, et al. (2011) A new approach to explore the impact of freeze-thaw cycling on protein structure: hydrogen/deuterium exchange mass spectrometry (HX-MS). Pharmaceutical Research. 28: 1179-93
Zhang A, Jordan JL, Ivanova MI, et al. (2010) Molecular level insights into thermally induced α-chymotrypsinogen A amyloid aggregation mechanism and semiflexible protofibril morphology. Biochemistry. 49: 10553-64
Cierpicki T, Bielnicki J, Zheng M, et al. (2009) The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA. Protein Science : a Publication of the Protein Society. 18: 2067-79
Qi W, Zhang A, Good TA, et al. (2009) Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability. Biochemistry. 48: 8908-19
Zhang A, Qi W, Good TA, et al. (2009) Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange. Biophysical Journal. 96: 1091-104
Qi W, Zhang A, Patel D, et al. (2008) Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: application to Abeta(1-40) fibrillogenesis. Biotechnology and Bioengineering. 100: 1214-27
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