Homme W. Hellinga

Affiliations: 
Duke University, Durham, NC 
Area:
Biochemistry
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"Homme Hellinga"
Mean distance: 4976.62
 

Children

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Jonathan S. Marvin grad student 2001 Duke
Michael S. Wisz grad student 2002 Duke
Mary A. Dwyer grad student 2004 Duke
Shahir S. Rizk grad student 2006 Duke
Matthew J. Cuneo grad student 2007 Duke
Aleksandr E. Miklos grad student 2008 Duke
Curtis J. Layton grad student 2010 Duke
BETA: Related publications

Publications

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Shi Y, Hellinga HW, Beese LS. (2017) Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. Proceedings of the National Academy of Sciences of the United States of America
Mabanglo MF, Hast MA, Lubock NB, et al. (2014) Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Science : a Publication of the Protein Society. 23: 289-301
Grimley JS, Li L, Wang W, et al. (2013) Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16297-309
Wang W, Wu EY, Hellinga HW, et al. (2012) Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. The Journal of Biological Chemistry. 287: 28215-26
Wang W, Hellinga HW, Beese LS. (2011) Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 17644-8
Hast MA, Nichols CB, Armstrong SM, et al. (2011) Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens. The Journal of Biological Chemistry. 286: 35149-62
Layton CJ, Hellinga HW. (2011) Integration of cell-free protein coexpression with an enzyme-linked immunosorbent assay enables rapid analysis of protein-protein interactions directly from DNA. Protein Science : a Publication of the Protein Society. 20: 1432-8
Layton CJ, Hellinga HW. (2011) Quantitation of protein-protein interactions by thermal stability shift analysis. Protein Science : a Publication of the Protein Society. 20: 1439-50
Orans J, McSweeney EA, Iyer RR, et al. (2011) Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell. 145: 212-23
Isom DG, Marguet PR, Oas TG, et al. (2011) A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity. Proteins. 79: 1034-47
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