Kathleen M. Holtz, Ph.D.
Affiliations: | 2000 | Boston College, Newton, MA, United States |
Area:
BiochemistryGoogle:
"Kathleen Holtz"Mean distance: 5687.57
Parents
Sign in to add mentor| Evan R. Kantrowitz | grad student | 2000 | Boston College | |
| (Investigating mechanistic details in the catalytic reaction of alkaline phosphatase from Escherichia coli.) | ||||
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| Stec B, Holtz KM, Wojciechowski CL, et al. (2005) Structure of the wild-type TEM-1 beta-lactamase at 1.55 A and the mutant enzyme Ser70Ala at 2.1 A suggest the mode of noncovalent catalysis for the mutant enzyme. Acta Crystallographica. Section D, Biological Crystallography. 61: 1072-9 |
| Holtz KM, Catrina IE, Hengge AC, et al. (2000) Mutation of Arg-166 of alkaline phosphatase alters the thio effect but not the transition state for phosphoryl transfer. Implications for the interpretation of thio effects in reactions of phosphatases. Biochemistry. 39: 9451-8 |
| Stec B, Holtz KM, Kantrowitz ER. (2000) A revised mechanism for the alkaline phosphatase reaction involving three metal ions. Journal of Molecular Biology. 299: 1303-11 |
| Holtz KM, Stec B, Myers JK, et al. (2000) Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes. Protein Science : a Publication of the Protein Society. 9: 907-15 |
| Holtz KM, Kantrowitz ER. (1999) The mechanism of the alkaline phosphatase reaction: insights from NMR, crystallography and site-specific mutagenesis. Febs Letters. 462: 7-11 |
| Holtz KM, Stec B, Kantrowitz ER. (1999) A model of the transition state in the alkaline phosphatase reaction. The Journal of Biological Chemistry. 274: 8351-4 |
| Widlanski TS, Myers JK, Stec B, et al. (1997) The road less travelled: taming phosphatases. Chemistry & Biology. 4: 489-92 |