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Jiarong Xia, Ph.D.

Affiliations: 
2007 Boston College, Newton, MA, United States 
Area:
General Biophysics
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"Jiarong Xia"
Mean distance: 5687.57
 
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Evan R. Kantrowitz grad student 2007 Boston College
 (Studies of the structure and function of the allosteric enzyme aspartate transcarbamoylase.)

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Publications

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Stieglitz KA, Xia J, Kantrowitz ER. (2009) The first high pH structure of Escherichia coli aspartate transcarbamoylase. Proteins. 74: 318-27
Wang Q, Xia J, Guallar V, et al. (2008) Mechanism of thermal decomposition of carbamoyl phosphate and its stabilization by aspartate and ornithine transcarbamoylases. Proceedings of the National Academy of Sciences of the United States of America. 105: 16918-23
West JM, Xia J, Tsuruta H, et al. (2008) Time evolution of the quaternary structure of Escherichia coli aspartate transcarbamoylase upon reaction with the natural substrates and a slow, tight-binding inhibitor. Journal of Molecular Biology. 384: 206-18
Cardia JP, Eldo J, Xia J, et al. (2008) Use of L-asparagine and N-phosphonacetyl-L-asparagine to investigate the linkage of catalysis and homotropic cooperativity in E. coli aspartate transcarbomoylase. Proteins. 71: 1088-96
Eldo J, Cardia JP, O'Day EM, et al. (2006) N-phosphonacetyl-L-isoasparagine a potent and specific inhibitor of Escherichia coli aspartate transcarbamoylase. Journal of Medicinal Chemistry. 49: 5932-8
Heng S, Stieglitz KA, Eldo J, et al. (2006) T-state inhibitors of E. coli aspartate transcarbamoylase that prevent the allosteric transition. Biochemistry. 45: 10062-71
Stieglitz KA, Pastra-Landis SC, Xia J, et al. (2005) A single amino acid substitution in the active site of Escherichia coli aspartate transcarbamoylase prevents the allosteric transition. Journal of Molecular Biology. 349: 413-23
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