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Jay M. West, Ph.D.

Affiliations: 
2009 Boston College, Newton, MA, United States 
Area:
Biochemistry
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"Jay West"
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Evan R. Kantrowitz grad student 2009 Boston College
 (Probing the mechanism of the allosteric transition of aspartate transcarbamoylase via fluorescence, physical entrapment, and small-angle x-ray scattering.)

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Publications

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Pavlopoulos S, Pelekoudas DN, Benchama O, et al. (2017) Secretion, isotopic labeling and deglycosylation of N-Acylethanolamine acid amidase for biophysical studies. Protein Expression and Purification
Johnston M, Bhatt SR, Sikka S, et al. (2012) Assay and inhibition of diacylglycerol lipase activity Bioorganic and Medicinal Chemistry Letters. 22: 4585-4592
Guo W, West JM, Dutton AS, et al. (2012) Trapping and structure determination of an intermediate in the allosteric transition of aspartate transcarbamoylase. Proceedings of the National Academy of Sciences of the United States of America. 109: 7741-6
West JM, Zvonok N, Whitten KM, et al. (2012) Mass spectrometric characterization of human N -acylethanolamine- hydrolyzing acid amidase Journal of Proteome Research. 11: 972-981
West JM, Xia J, Tsuruta H, et al. (2008) Time evolution of the quaternary structure of Escherichia coli aspartate transcarbamoylase upon reaction with the natural substrates and a slow, tight-binding inhibitor. Journal of Molecular Biology. 384: 206-18
West JM, Tsuruta H, Kantrowitz ER. (2004) A fluorescent probe-labeled Escherichia coli aspartate transcarbamoylase that monitors the allosteric conformational state. The Journal of Biological Chemistry. 279: 945-51
West JM, Kantrowitz ER. (2003) Trapping specific quaternary states of the allosteric enzyme aspartate transcarbamoylase in silica matrix sol-gels. Journal of the American Chemical Society. 125: 9924-5
Chan RS, Sakash JB, Macol CP, et al. (2002) The role of intersubunit interactions for the stabilization of the T state of Escherichia coli aspartate transcarbamoylase. The Journal of Biological Chemistry. 277: 49755-60
West JM, Tsuruta H, Kantrowitz ER. (2002) Stabilization of the R allosteric structure of Escherichia coli aspartate transcarbamoylase by disulfide bond formation. The Journal of Biological Chemistry. 277: 47300-4
Hack ES, Vorobyova T, Sakash JB, et al. (2000) Characterization of the aspartate transcarbamoylase from Methanococcus jannaschii. The Journal of Biological Chemistry. 275: 15820-7
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