Christal D. Sohl, Ph.D.
Affiliations: | 2005-2010 | Biochemistry | Vanderbilt University, Nashville, TN |
| 2010-2015 | Pharmacology | Yale University School of Medicine, New Haven, CT | |
| 2015- | Biochemistry | San Diego State University, San Diego, CA, United States |
Area:
BiochemistryGoogle:
"Christal Sohl"Mean distance: 11375.1
Parents
Sign in to add mentor| F Peter Guengerich | grad student | 2010 | Vanderbilt | |
| (Kinetic analysis of the multi-step cytochrome P450 1A2 and 19A1 enzymes.) | ||||
| Karen S. Anderson | post-doc | 2010-2015 | Yale School of Medicine | |
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Publications
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| Sohl CD, Matteo DA, Wells G, et al. (2020) The Catalytic Features of IDH1 Mutations Can Drive Neomorphic Activity, Phenotype Severity, and Inhibitor Binding The Faseb Journal. 34: 1-1 |
| Chambers J, Miller W, Quichocho G, et al. (2019) Water networks and correlated motions in mutant IDH1 are critical for allosteric inhibitor binding and activity. Biochemistry |
| Kennedy MA, Xu Z, Wu Y, et al. (2019) A Tie2 kinase mutation causing venous malformations increases phosphorylation rates and enhances cooperativity. Biochemical and Biophysical Research Communications |
| Weeks JL, Wells G, Alexander S, et al. (2019) Abstract 4381: Investigating the reversible MDH1 catalytic reaction in squamous non-small cell lung cancer Cancer Research. 79: 4381-4381 |
| Ryan MR, Sohl CD, Luo B, et al. (2018) The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT. Molecular Cancer Research : McR |
| Matteo DA, Wells GA, Luna LA, et al. (2018) Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants. The Biochemical Journal |
| Matteo DA, Grunseth AJ, Gonzalez ER, et al. (2017) Molecular Mechanisms of Isocitrate Dehydrogenase 1 (IDH1) Mutations Identified in Tumors: The Role of Size and Hydrophobicity at Residue 132 on Catalytic Efficiency. The Journal of Biological Chemistry |
| Sohl CD, Szymanski MR, Mislak AC, et al. (2015) Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ. Proceedings of the National Academy of Sciences of the United States of America. 112: 8596-601 |
| Sohl CD, Ray S, Sweasy JB. (2015) Pools and Pols: Mechanism of a mutator phenotype. Proceedings of the National Academy of Sciences of the United States of America. 112: 5864-5 |
| Sohl CD, Ryan MR, Luo B, et al. (2015) Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. Acs Chemical Biology. 10: 1319-29 |