Christal D. Sohl, Ph.D.

Affiliations: 
2005-2010 Biochemistry Vanderbilt University, Nashville, TN 
 2010-2015 Pharmacology Yale University School of Medicine, New Haven, CT 
 2015- Biochemistry San Diego State University, San Diego, CA, United States 
Area:
Biochemistry
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"Christal Sohl"
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Parents

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F Peter Guengerich grad student 2010 Vanderbilt
 (Kinetic analysis of the multi-step cytochrome P450 1A2 and 19A1 enzymes.)
Karen S. Anderson post-doc 2010-2015 Yale School of Medicine
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Publications

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Ryan MR, Sohl CD, Luo B, et al. (2018) The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT. Molecular Cancer Research : McR
Sohl CD, Szymanski MR, Mislak AC, et al. (2016) Erratum: Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (8596-8601) DOI: 10.1073/pnas.1421733112) Proceedings of the National Academy of Sciences of the United States of America. 113
Sohl CD, Szymanski MR, Mislak AC, et al. (2015) Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ. Proceedings of the National Academy of Sciences of the United States of America. 112: 8596-601
Sohl CD, Ryan MR, Luo B, et al. (2015) Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. Acs Chemical Biology. 10: 1319-29
Sohl CD, Ryan M, Luo B, et al. (2015) Abstract 2436: Understanding the molecular mechanism of targeted kinase inhibitor resistance mediated by the FGFR1 gatekeeper mutation Cancer Research. 75: 2436-2436
Sohl CD, Ryan MR, Luo B, et al. (2015) Illuminating the molecular ,mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: The Achilles' heel of targeted therapy Acs Chemical Biology. 10: 1319-1329
Towle-Weicksel JB, Dalal S, Sohl CD, et al. (2014) Fluorescence resonance energy transfer studies of DNA polymerase β the critical role of fingers domain movements and a novel non-covalent step During nucleotide selection Journal of Biological Chemistry. 289: 16541-16550
Muftuoglu Y, Sohl CD, Mislak AC, et al. (2014) Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics. Antiviral Research. 106: 1-4
Sohl CD, Kasiviswanathan R, Copeland WC, et al. (2013) Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients. Human Molecular Genetics. 22: 1074-85
Cheng Q, Sohl CD, Yoshimoto FK, et al. (2012) Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. The Journal of Biological Chemistry. 287: 29554-67
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