Richard J. Isaacs, Ph.D.
Affiliations: | 2004 | University of Kentucky, Lexington, KY |
Area:
BiochemistryGoogle:
"Richard Isaacs"Mean distance: 13271
Parents
Sign in to add mentor| H Peter Spielmann | grad student | 2004 | University of Kentucky | |
| (Structure and dynamics in normal, mismatched, and methylated DNA.) | ||||
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Publications
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| Isaacs RJ, Spielmann HP. (2004) A model for initial DNA lesion recognition by NER and MMR based on local conformational flexibility. Dna Repair. 3: 455-64 |
| Isaacs RJ, Spielmann HP. (2004) Insight into G[bond]T mismatch recognition using molecular dynamics with time-averaged restraints derived from NMR spectroscopy. Journal of the American Chemical Society. 126: 583-90 |
| Chehade KA, Kiegiel K, Isaacs RJ, et al. (2002) Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase. Journal of the American Chemical Society. 124: 8206-19 |
| Isaacs RJ, Rayens WS, Spielmann HP. (2002) Structural differences in the NOE-derived structure of G-T mismatched DNA relative to normal DNA are correlated with differences in (13)C relaxation-based internal dynamics. Journal of Molecular Biology. 319: 191-207 |
| Micali E, Chehade KA, Isaacs RJ, et al. (2001) Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups. Biochemistry. 40: 12254-65 |
| Isaacs RJ, Spielmann HP. (2001) NMR evidence for mechanical coupling of phosphate B(I)-B(II) transitions with deoxyribose conformational exchange in DNA. Journal of Molecular Biology. 311: 149-60 |
| Isaacs RJ, Spielmann HP. (2001) Relationship of DNA structure to internal dynamics: correlation of helical parameters from NOE-based NMR solution structures of d(GCGTACGC)(2) and d(CGCTAGCG)(2) with (13)C order parameters implies conformational coupling in dinucleotide units. Journal of Molecular Biology. 307: 525-40 |