Richard H. Cote

Affiliations: 
University of New Hampshire, Durham, NH, United States 
Area:
Biochemistry
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"Richard Cote"
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Children

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Hongmei Mou grad student 2001 UNH
Angela W. Norton grad student 2002 UNH
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Publications

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Zeng-Elmore X, Gao XZ, Pellarin R, et al. (2014) Molecular architecture of photoreceptor phosphodiesterase elucidated by chemical cross-linking and integrative modeling. Journal of Molecular Biology. 426: 3713-28
Cahill KB, Quade JH, Carleton KL, et al. (2012) Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6. The Journal of Biological Chemistry. 287: 41406-16
Zhang XJ, Gao XZ, Yao W, et al. (2012) Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) γ-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1). The Journal of Biological Chemistry. 287: 26312-20
Matte SL, Laue TM, Cote RH. (2012) Characterization of conformational changes and protein-protein interactions of rod photoreceptor phosphodiesterase (PDE6). The Journal of Biological Chemistry. 287: 20111-21
Zhang XJ, Skiba NP, Cote RH. (2010) Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin. The Journal of Biological Chemistry. 285: 4455-63
Liu YT, Matte SL, Corbin JD, et al. (2009) Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitors. The Journal of Biological Chemistry. 284: 31541-7
Zhang XJ, Cahill KB, Elfenbein A, et al. (2008) Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6. The Journal of Biological Chemistry. 283: 29699-705
Pentia DC, Hosier S, Cote RH. (2006) The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties. The Journal of Biological Chemistry. 281: 5500-5
Zhang H, Hosier S, Terew JM, et al. (2005) Assay and functional properties of PrBP(PDEdelta), a prenyl-binding protein interacting with multiple partners. Methods in Enzymology. 403: 42-56
Zhang X, Feng Q, Cote RH. (2005) Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors. Investigative Ophthalmology & Visual Science. 46: 3060-6
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