Jack W. Szostak

Genetics Harvard Medical School, Boston, MA, United States 
origin of life
"Jack W. Szostak"

The Nobel Prize in Physiology or Medicine 2009 was awarded jointly to Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.
2009 Nobel Prize in Physiology or Medicine (shared)

Mean distance: 7.48 (cluster 10)
Cross-listing: Astrobiology Academic Family Tree - Telomere and Telomerase Tree


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Ray J. Wu grad student 1977 Cornell


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Rajat Rohatgi research assistant 1992-1994 Harvard Medical School
Barbara Dunn grad student Harvard Medical School (Telomere and Telomerase Tree)
Jon Lorsch grad student Harvard Medical School
Stephanie W. Ruby grad student (Plant Biology Tree)
Terry Orr-Weaver grad student 1979-1983 (FlyTree)
Andrew W. Murray grad student 1978-1984 Harvard Medical School
Jennifer A. Doudna grad student 1989 Harvard
Rachel Green grad student 1992 Harvard
David P. Bartel grad student 1993 Harvard
Hiroaki Suga grad student 1994-1997 Harvard Medical School
Ananya Das grad student 2000 Harvard
Jack D. Pollard grad student 2000 Harvard
Jonathan M. Urbach grad student 2000 Harvard
Shelly M. Fujikawa grad student 2003 Harvard
Glen S. Cho grad student 2004 Harvard
James M. Carothers grad student 2005 Harvard
Irene A. Chen grad student 2005 Harvard
Justin K. Ichida grad student 2007 Harvard
Raphael J. Bruckner grad student 2010 Harvard
Mark P. Elenko grad student 2010 Harvard
Jason P. Schrum grad student 2010 Harvard
Simon G. Trevino grad student 2011 Harvard
Itay Budin grad student 2012 Harvard
Katarzyna P. Adamala grad student 2007-2013 Harvard Medical School (Neurotree)
Chun Pong Tam grad student 2013-2018 Harvard Medical School
John C. Chaput post-doc Havard Medical School
Saurja DasGupta post-doc Harvard Medical School
Dean S. Dawson post-doc (Cell Biology Tree)
Andrew D. Ellington post-doc MGH (Cell Biology Tree)
Aaron E. Engelhart post-doc
Yollete V. Guillen Schlippe post-doc (Cell Biology Tree)
Matthew C. Hartman post-doc
Matthew Powner post-doc Harvard Medical School
Michael Famulok post-doc 1990-1992 Massachusetts General Hospital & Harvard Medical School
Richard W. Roberts post-doc 1993-1997 Harvard Medical School
Sheref S. Mansy post-doc 2007
Andrej Lupták post-doc 2002-2007 Harvard Medical School
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Wu LF, Liu Z, Roberts SJ, et al. (2022) Template-Free Assembly of Functional RNAs by Loop-Closing Ligation. Journal of the American Chemical Society. 144: 13920-13927
Zhang SJ, Duzdevich D, Ding D, et al. (2022) Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying. Proceedings of the National Academy of Sciences of the United States of America. 119: e2116429119
Radakovic A, DasGupta S, Wright TH, et al. (2022) Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides. Proceedings of the National Academy of Sciences of the United States of America. 119
Ding D, Zhou L, Giurgiu C, et al. (2022) Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates. Nucleic Acids Research. 50: 35-45
Giurgiu C, Fang Z, Aitken HRM, et al. (2021) Structure-activity relationships in nonenzymatic template-directed RNA synthesis. Angewandte Chemie (International Ed. in English)
Duzdevich D, Carr CE, Ding D, et al. (2021) Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension. Nucleic Acids Research
Kim SC, O'Flaherty DK, Giurgiu C, et al. (2021) The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis. Journal of the American Chemical Society
Mojarro A, Jin L, Szostak JW, et al. (2021) In search of the RNA world on Mars. Geobiology
Radakovic A, Wright TH, Lelyveld VS, et al. (2021) A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry. Biochemistry
O'Flaherty DK, Zhou L, Szostak JW. (2020) Nonenzymatic RNA-templated Synthesis of N3'→P5' Phosphoramidate DNA. Bio-Protocol. 10: e3734
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