Philip L. Lorenzi, Ph.D.
Affiliations: | 2005 | University of Michigan, Ann Arbor, Ann Arbor, MI |
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"Philip Lorenzi"Mean distance: 3619.36
Parents
Sign in to add mentor| Gordon L. Amidon | grad student | 2005 | University of Michigan | |
| (Bioevasive prodrugs: Identification and evasion of nucleoside-metabolizing enzymes.) | ||||
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Publications
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| Van Trimpont M, Schalk AM, De Visser Y, et al. (2022) stabilization of a less toxic asparaginase variant leads to a durable anti-tumor response in acute leukemia. Haematologica |
| Grima-Reyes M, Vandenberghe A, Nemazanyy I, et al. (2022) Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression. Science Advances. 8: eabn6491 |
| Becker LM, O'Connell JT, Vo AP, et al. (2020) Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer. Cell Reports. 31: 107701 |
| Lubkowski J, Vanegas JM, Chan WK, et al. (2020) The mechanism of catalysis by L-asparaginase. Biochemistry |
| Petchampai N, Isoe J, Horvath TD, et al. (2020) Mass spectrometry-based stable-isotope tracing uncovers metabolic alterations in pyruvate kinase-deficient Aedes aegypti mosquitoes. Insect Biochemistry and Molecular Biology. 103366 |
| Qian X, Li X, Shi Z, et al. (2019) PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1. Molecular Cell |
| Tabe Y, Lorenzi PL, Konopleva M. (2019) Amino Acid Metabolism in Hematologic Malignancies and the Era of Targeted Therapy. Blood |
| Chan WK, Horvath TD, Tan L, et al. (2019) Glutaminase activity of L-asparaginase contributes to durable preclinical activity against acute lymphoblastic leukemia. Molecular Cancer Therapeutics |
| Zhang L, Yao Y, Zhang S, et al. (2019) Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma. Science Translational Medicine. 11 |
| Piya S, Mu H, Bhattacharya S, et al. (2019) BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment. The Journal of Clinical Investigation. 130 |