James T. Patterson
Affiliations: | 2006-2011 | Chemistry | Indiana University, Bloomington, Bloomington, IN, United States |
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Parents
Sign in to add mentorDonald H. Burke | research assistant | 2002-2005 | ||
Richard DiMarchi | grad student | 2006-2011 | Indiana University | |
(Selective GLP-1 receptor antagonists and glucagon/GLP-1 co-agonists discovered through an investigation into the structure-activity relationship in glucagon-related peptides.) | ||||
Carlos F. Barbas, III | post-doc | 2012-2014 | Scripps Institute |
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Publications
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Patterson JT, Wilson HD, Asano S, et al. (2016) Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation. Bioconjugate Chemistry |
Li X, Patterson JT, Sarkar M, et al. (2015) Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues. Bioconjugate Chemistry |
Patterson JT, Asano S, Li X, et al. (2014) Improving the serum stability of site-specific antibody conjugates with sulfone linkers. Bioconjugate Chemistry. 25: 1402-7 |
Liu J, Gaj T, Patterson JT, et al. (2014) Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering. Plos One. 9: e85755 |
Patterson JT, Li P, Day JW, et al. (2013) A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction. Molecular Metabolism. 2: 86-91 |
Kuna RS, Girada SB, Asalla S, et al. (2013) Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells. American Journal of Physiology. Endocrinology and Metabolism. 305: E161-70 |
Patterson JT, Day JW, Gelfanov VM, et al. (2011) Functional association of the N-terminal residues with the central region in glucagon-related peptides. Journal of Peptide Science : An Official Publication of the European Peptide Society. 17: 659-66 |
Day JW, Li P, Patterson JT, et al. (2011) Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action. Journal of Peptide Science : An Official Publication of the European Peptide Society. 17: 218-25 |
Patterson JT, Ottaway N, Gelfanov VM, et al. (2011) A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1. Acs Chemical Biology. 6: 135-45 |
Nickens DG, Bardiya N, Patterson JT, et al. (2010) Template-directed ligation of tethered mononucleotides by t4 DNA ligase for kinase ribozyme selection. Plos One. 5: e12368 |