J. Eric Gouaux, Jr.
Affiliations: | Biochemistry and Molecular Biology | Oregon Health and Science University, Portland, OR |
Area:
molecular mechanisms for the function of receptors and transporters at chemical synapsesWebsite:
http://www.ohsu.edu/xd/research/centers-institutes/vollum/faculty/faculty-profile.cfm?facultyID=422Google:
"James Eric Gouaux, Jr."Bio:
http://www.nasonline.org/member-directory/members/20022351.html
http://www.ohsu.edu/xd/research/centers-institutes/vollum/faculty/gouauxlab.cfm
http://www.hhmi.org/research/molecular-mechanisms-receptors-and-transporters
Mean distance: 16.52 (cluster 11) | S | N | B | C | P |
Cross-listing: Neurotree
Parents
Sign in to add mentor| William N. Lipscomb | grad student | 1989 | Harvard | |
| (Crystallographic studies of aspartate carbamoyltransferase) | ||||
Children
Sign in to add trainee| Chia-Hsueh Lee | grad student | OHSU | |
| Mark L. Mayer | grad student | Columbia (Neurotree) | |
| Neali A. Armstrong | grad student | 2001 | Columbia (Microtree) |
| Rongsheng Jin | grad student | 2003 | Columbia (Microtree) |
| Michelle Montoya | grad student | 2004 | Columbia (Microtree) |
| Nelson B. Olivier | grad student | 2004 | Columbia (Microtree) |
| Toshi Kawate | grad student | 2001-2005 | Columbia (Neurotree) |
| Lei Chen | post-doc | OHSU | |
| Hiro Furukawa | post-doc | CSHL | |
| Ryan E. Hibbs | post-doc | OHSU | |
| Steven E. Mansoor | post-doc | OHSU | |
| Alexander Sobolevsky | post-doc | Columbia Medical Center | |
| Olga V. Boudker | post-doc | 2000-2005 | Columbia |
| Shujia Zhu | post-doc | 2013-2016 | OHSU (Neurotree) |
| Juan Du | post-doc | 2012-2017 | OHSU |
| Wei Lü | post-doc | 2012-2017 | OHSU |
| Jingpeng Ge | post-doc | 2016-2021 | OHSU |
| Hongtao Zhu | post-doc | 2015-2022 |
Collaborators
Sign in to add collaborator| Mark L. Mayer | collaborator | 1990-2000 | NIH (Neurotree) | |
| (Sabbatical) | ||||
BETA: Related publications
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Publications
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| Robert A, Armstrong N, Gouaux JE, et al. (2005) AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3752-62 |
| Kosman RP, Gouaux JE, Lipscomb WN. (1993) Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity. Proteins. 15: 147-76 |
| Gouaux JE, Lipscomb WN. (1990) Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH. Biochemistry. 29: 389-402 |
| Gouaux JE, Stevens RC, Lipscomb WN. (1990) Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH. Biochemistry. 29: 7702-15 |
| Stevens RC, Gouaux JE, Lipscomb WN. (1990) Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution. Biochemistry. 29: 7691-701 |
| Gouaux JE, Lipscomb WN, Middleton SA, et al. (1989) Structure of a single amino acid mutant of aspartate carbamoyltransferase at 2.5-A resolution: implications for the cooperative mechanism. Biochemistry. 28: 1798-803 |
| Gouaux JE, Lipscomb WN. (1989) Structural transitions in crystals of native aspartate carbamoyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 86: 845-8 |
| Gouaux JE, Stevens RC, Ke HM, et al. (1989) Crystal structure of the Glu-239----Gln mutant of aspartate carbamoyltransferase at 3.1-A resolution: an intermediate quaternary structure. Proceedings of the National Academy of Sciences of the United States of America. 86: 8212-6 |
| Gouaux JE, Lipscomb WN. (1988) Three-dimensional structure of carbamoyl phosphate and succinate bound to aspartate carbamoyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 85: 4205-8 |
| Gouaux JE, Krause KL, Lipscomb WN. (1987) The catalytic mechanism of Escherichia coli aspartate carbamoyltransferase: a molecular modelling study. Biochemical and Biophysical Research Communications. 142: 893-7 |