Jason A. Mears, Ph.D.
Affiliations: | 1999-2005 | Biochemistry and Molecular Genetics | University of Alabama, Birmingham, Birmingham, AL, United States |
| 2005-2010 | Laboratory of Cell & Molecular Biology | Natiional Institutes of Health, NIDDK | |
| 2010- | Pharmacology | Case Western Reserve University, Cleveland Heights, OH, United States |
Area:
Biochemistry, General Biophysics, Structural Biology, Cryo-EM, mitochondrial dynamicsWebsite:
https://www.mearslab.com/Google:
"Jason Mears"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Stephen C. Harvey | grad student | 1999-2005 | UAB | |
| (Structural studies of an evolving ribosome.) | ||||
| Jenny Hinshaw | post-doc | 2005-2010 | NIH | |
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Publications
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| Rochon K, Bauer BL, Roethler NA, et al. (2024) Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1. Nature Communications. 15: 1328 |
| Pérez-Jover I, Rochon K, Hu D, et al. (2024) Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif. Nature Communications. 15: 52 |
| Pérez-Jover I, Rochon K, Hu D, et al. (2023) Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif. Research Square |
| Bauer BL, Rochon K, Liu JC, et al. (2023) Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery. Human Molecular Genetics |
| Robertson GL, Riffle S, Patel M, et al. (2023) DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs. Journal of Cell Science. 136 |
| Mears JA, Ramachandran R. (2022) Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division. Current Opinion in Physiology. 29 |
| Akinbiyi EO, Abramowitz LK, Bauer BL, et al. (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Scientific Reports. 11: 22106 |
| Montecinos-Franjola F, Bauer BL, Mears JA, et al. (2020) GFP fluorescence tagging alters dynamin-related protein 1 oligomerization dynamics and creates disassembly-refractory puncta to mediate mitochondrial fission. Scientific Reports. 10: 14777 |
| Clinton RW, Bauer BL, Mears JA. (2020) Affinity Purification and Functional Characterization of Dynamin-Related Protein 1. Methods in Molecular Biology (Clifton, N.J.). 2159: 41-53 |
| Hoppins S, Lackner LL, Lee JE, et al. (2020) In vitro and in vivo assays for mitochondrial fission and fusion. Methods in Cell Biology. 155: 491-518 |