James J. Truglio, Ph.D.

Affiliations: 
2004 Stony Brook University, Stony Brook, NY, United States 
Area:
Molecular Biology, General Biophysics, Biochemistry
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"James Truglio"
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Parents

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Caroline Kisker grad student 2004 SUNY Stony Brook
 (Crystallographic and biochemical studies of the nucleotide excision repair enzymes UvrB and UvrC, and the metabolically important enzyme xanthine dehydrogenase.)
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Publications

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Spagnuolo LA, Eltschkner S, Yu W, et al. (2017) Evaluating the contribution of transition state destabilization to changes in the residence time of triazole-based InhA inhibitors. Journal of the American Chemical Society
Gil AA, Haigney AL, Laptenok SP, et al. (2015) The Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: The Effect of the Y21 pKa on the Forward and Reverse Ground State Reactions. Journal of the American Chemical Society
Li HJ, Li X, Liu N, et al. (2011) Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member. Biochemistry. 50: 9532-44
Lu H, England K, am Ende C, et al. (2009) Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity. Acs Chemical Biology. 4: 221-31
Dietzel U, Kuper J, Doebbler JA, et al. (2009) Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase. The Journal of Biological Chemistry. 284: 8768-76
Wolski SC, Kuper J, Hänzelmann P, et al. (2008) Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. Plos Biology. 6: e149
Respicio L, Nair PA, Huang Q, et al. (2008) Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery. Tuberculosis (Edinburgh, Scotland). 88: 420-9
Karakas E, Truglio JJ, Croteau D, et al. (2007) Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. The Embo Journal. 26: 613-22
Kolappan S, Zwahlen J, Zhou R, et al. (2007) Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family. Biochemistry. 46: 946-53
Sullivan TJ, Truglio JJ, Boyne ME, et al. (2006) High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis. Acs Chemical Biology. 1: 43-53
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