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Nitai C. Giri, Ph.D.

Affiliations: 
2013 Chemistry University of Massachusetts, Amherst, Amherst, MA 
Area:
General Chemistry, Biochemistry, Toxicology
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"Nitai Giri"
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Parents

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Debashis Ray grad student 2006-2007 IIT Kharagpur
Michael J. Maroney grad student 2013 U Mass Amherst
 (Structural investigations of early intermediates and nickel inhibition complexes of human DNA and histone demethylases.)

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Publications

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Mondal A, Lai RY, Fedoseyenko D, et al. (2023) Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis in . Journal of the American Chemical Society
Weitz AC, Giri N, Frederick RE, et al. (2018) Spectroscopy and DFT Calculations of Flavo-Diiron Nitric Oxide Reductase Identify Bridging Structures of NO-Coordinated Diiron Intermediates. Acs Catalysis. 8: 11704-11715
Weitz AC, Giri N, Caranto JD, et al. (2017) Spectroscopy and DFT calculations of a flavo-diiron enzyme implicate new diiron site structures. Journal of the American Chemical Society
Chen H, Giri NC, Zhang R, et al. (2017) Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. The Journal of Biological Chemistry. 292: 10743
Caranto JD, Weitz A, Giri N, et al. (2014) A diferrous-dinitrosyl intermediate in the N2O-generating pathway of a deflavinated flavo-diiron protein. Biochemistry. 53: 5631-7
Giri NC, Passantino L, Sun H, et al. (2013) Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy. Biochemistry. 52: 4168-83
Flagg SC, Giri N, Pektas S, et al. (2012) Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2). Biochemistry. 51: 6654-66
Giri NC, Sun H, Chen H, et al. (2011) X-ray absorption spectroscopy structural investigation of early intermediates in the mechanism of DNA repair by human ABH2. Biochemistry. 50: 5067-76
Chen H, Giri NC, Zhang R, et al. (2010) Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. The Journal of Biological Chemistry. 285: 7374-83
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