Junichi Komoto, Ph.D.

2002 University of Kansas, Lawrence, KS, United States 
Molecular Biology, Biochemistry, General Biophysics
"Junichi Komoto"
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Fusao Takusagawa grad student 2002 University of Kansas
 (Structures and functions of key enzymes in methyl cycle: Guanidinoacetate methyltransferase and S-adenosylhomocysteine hydrolase.)
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Yamada T, Komoto J, Kasuya T, et al. (2008) A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. Biochimica Et Biophysica Acta. 1780: 809-18
Yamada T, Komoto J, Lou K, et al. (2007) Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. Biochemical Pharmacology. 73: 981-9
Komoto J, Yamada T, Watanabe K, et al. (2006) Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost. Biochemistry. 45: 1987-96
Yamada T, Komoto J, Saiki K, et al. (2006) Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans. Protein Science : a Publication of the Protein Society. 15: 362-72
Yamada T, Takata Y, Komoto J, et al. (2005) Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89. The International Journal of Biochemistry & Cell Biology. 37: 2417-35
Yamada T, Komoto J, Watanabe K, et al. (2005) Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2). Journal of Molecular Biology. 348: 1163-76
Komoto J, Yamada T, Takata Y, et al. (2004) Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes. Biochemistry. 43: 14385-94
Komoto J, Yamada T, Watanabe K, et al. (2004) Crystal structure of human prostaglandin F synthase (AKR1C3). Biochemistry. 43: 2188-98
Komoto J, Yamada T, Takata Y, et al. (2004) Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of S-adenosylmethionine synthesis from ATP and Met. Biochemistry. 43: 1821-31
Yamada T, Komoto J, Takata Y, et al. (2003) Crystal structure of serine dehydratase from rat liver. Biochemistry. 42: 12854-65
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