James R. Broughman, Ph.D.

Affiliations: 
2001 Kansas State University, Manhattan, KS, United States 
Area:
Biochemistry, Medicine and Surgery
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John Matthew Tomich grad student 2001 Kansas State University
 (Development of synthetic peptide derivatives as therapeutics for cystic fibrosis.)
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Publications

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Shank LP, Broughman JR, Takeguchi W, et al. (2006) Redesigning channel-forming peptides: amino acid substitutions that enhance rates of supramolecular self-assembly and raise ion transport activity. Biophysical Journal. 90: 2138-50
Broughman JR, Brandt RM, Hastings C, et al. (2004) Channel-forming peptide modulates transepithelial electrical conductance and solute permeability. American Journal of Physiology. Cell Physiology. 286: C1312-23
Broughman JR, Shank LP, Prakash O, et al. (2002) Structural implications of placing cationic residues at either the NH2- or COOH-terminus in a pore-forming synthetic peptide. The Journal of Membrane Biology. 190: 93-103
Broughman JR, Shank LP, Takeguchi W, et al. (2002) Distinct structural elements that direct solution aggregation and membrane assembly in the channel-forming peptide M2GlyR. Biochemistry. 41: 7350-8
Gao L, Broughman JR, Iwamoto T, et al. (2001) Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology. 281: L24-30
Broughman JR, Mitchell KE, Sedlacek RL, et al. (2001) NH(2)-terminal modification of a channel-forming peptide increases capacity for epithelial anion secretion. American Journal of Physiology. Cell Physiology. 280: C451-8
Forman HJ, Gao L, Broughman JR, et al. (2000) Glutathione transport and impaired antioxidant function in cystic fibrosis Pediatric Pulmonology. 30: 161-162
Iwamoto T, Broughman JR, Tomich JM, et al. (1998) The structures and functions of ATP receptors Neuroscience Research. 31
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